Effects of biomimetic hydroxyapatite coatings on osteoimmunomodulation
Effects of biomimetic hydroxyapatite coatings on osteoimmunomodulation
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仿生羟基磷灰石涂层对骨免疫调节的影响
DOI：
10.1016/j.msec.2021.112640
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发表时间：
2022-03-01
影响因子：
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通讯作者：
Xiao, Jun
中科院分区：
文献类型：
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作者：
Jiang, Jiawei;Liu, Wenbin;Xiao, Jun
巨噬细胞在骨再生中起着非常重要的作用。在骨组织工程中，通过改变生物材料的理化性质来调控巨噬细胞体内基因和蛋白的表达，对促进成骨和血管生成具有重要意义。在此基础上，我们研究了仿生羟基磷灰石涂层与巨噬细胞的相互作用及其对骨生成和血管生成的影响。在本研究中，我们发现仿生羟基磷灰石涂层可以抑制炎症因子（肿瘤坏死因子- α， tnf - α）的表达，同时促进骨形态发生蛋白-2 （BMP-2）和血管内皮生长因子（VEGF）的表达，从而促进血管内皮细胞的血管生成和间充质干细胞的成骨分化。本研究表明，仿生羟基磷灰石涂层改性聚乳酸内酯（PCI.）具有良好的骨免疫调节性能，是一种很有应用前景的涂层材料。
Macrophages play a very fundamental role in bone regeneration. Changing the physicochemical properties of biomaterials to regulate the genes and protein expressions of Macrophages in vivo is of great significance to promote osteogenesis and angiogenesis in bone tissue engineering. I lerein, we investigated the interaction of biomimetic hydroxyapatite coatings with macrophages and the subsequent impact on osteogenesis and angiogenesis. In this study, we found that biomimetic hydroxyapatite coating could inhibit the expression of inflammatory factors (tumor necrosis factor-alpha, TNF-alpha) while promoting bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF), thereby promoting angiogenesis of vascular endothelial cells and osteogenic differentiation of mesenchymal stem cells. This study demonstrated that biomimetic hydroxyapatite coating modified polycapmlactone (PCI.) possessed an excellent osteoimmunomodulatory property and was a promising coating material for the application.