Grades I-II intraventricular hemorrhage in extremely low birth weight infants: Effects on neurodevelopment
Grades I-II intraventricular hemorrhage in extremely low birth weight infants: Effects on neurodevelopment
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DOI：
10.1016/j.jpeds.2006.04.002
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发表时间：
2006-08-01
影响因子：
5.1
通讯作者：
Hack, Maureen
中科院分区：
文献类型：
--
作者：
Patra, Kousiki;Wilson-Costello, Deanne;Hack, Maureen
研究设计1992年至2000年我中心收治的706例无严重畸形的极低出生体重儿中，537例存活至20个月的校正年龄（CA），并进行了头颅超声检查，其中490人（91%）进行了完整的神经发育评估。排除了有严重颅脑超声异常或脑膜炎的婴儿，剩下362名婴儿，其中258名婴儿的颅脑超声正常，104名婴儿有孤立的I-II级IVH。两组的出生体重（808克vs 801克）和胎龄（26.5周vs 26.3周）相似。在20个月的CA时，将头颅超声正常的婴儿与I-II级IVH的婴儿的结局进行比较。结果包括贝利婴儿发育量表、智力发育指数（MDI）和主要感觉神经异常。使用逻辑回归来评估I-II级IVH对结局的影响，同时调整其他风险因素。结果患有I-II级IVH的极低出生体重婴儿的平均MDI评分显着低于头颅超声正常的婴儿（74 +/- 16 vs 79 +/- 14，P = 0.006）。他们的MDI比率更高
Objective To quantify the effect of grades I-II intraventricular hemorrhage (IVH) on, the neurosensory and cognitive outcomes of extremely low birth weight infants.Study design Of 706 extremely low birth weight infants without major malformations admitted to our center from 1992 to 2000, 537 survived to 20 months' corrected age (CA) and had cranial ultrasound studies performed, of whom 490 (91%) had complete neurodevelopmental assessments. Infants with severe cranial ultrasound abnormalities or meningitis were excluded, leaving a population of 362 infants, 258 of whom had a normal cranial ultrasound and 104 had an isolated grade I-II IVH. The groups had similar birth weight (808 vs 801 grams) and gestational age (26.5 vs 26.3 weeks). Outcomes of infants with normal cranial ultrasound were compared with those with grades I-II IVH at 20 months' CA. Outcomes included the Bayley Scales of Infant Development Mental Developmental Index (MDI) and major neurosensory abnormality. Logistic regression was used to assess the effect of grades I-II IVH on outcomes while adjusting for other risk factors.Results Extremely low birth weight infants with grades I-II IVH had a significantly lower mean MDI score than infants with normal cranial ultrasound (74 +/- 16 vs 79 +/- 14, P = .006). They had higher rates of MDI