N-heterocyclic carbene catalyzed annulation of benzofuran-2,3-diones and enals: a concise synthesis of spiro-bis-lactone.
N-heterocyclic carbene catalyzed annulation of benzofuran-2,3-diones and enals: a concise synthesis of spiro-bis-lactone.
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DOI：
10.1039/c3ob41028e
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发表时间：
2013-08
影响因子：
3.2
通讯作者：
Zedong Wang;Feng Wang;Xin Li;Jin‐Pei Cheng
中科院分区：
文献类型：
--
作者：
Zedong Wang;Feng Wang;Xin Li;Jin‐Pei Cheng
The N-heterocyclic carbene catalyzed annulation of benzofuran-2,3-diones and enals via homoenolate intermediates is described. The reaction provided a direct and efficient method for the synthesis of spiro-bis-lactones. The ketone-carbonyl group annulated products and the ester-carbonyl group annulated products can be obtained as major products with good yields by convenient catalyst regulation. Furthermore, commercially available thiazolium salt can also catalyze this reaction with modest yield.
