Neutron diffraction study of antibacterial bioactive calcium silicate sol-gel glasses containing silver
Neutron diffraction study of antibacterial bioactive calcium silicate sol-gel glasses containing silver
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DOI：
10.1111/ijag.12318
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发表时间：
2017-12
影响因子：
2.1
通讯作者：
D. Carta;Julian R. Jones;Sen Lin;G. Poologasundarampillai;R. J. Newport;D. Pickup
中科院分区：
文献类型：
--
作者：
D. Carta;Julian R. Jones;Sen Lin;G. Poologasundarampillai;R. J. Newport;D. Pickup
生物活性溶胶-凝胶钙硅玻璃可以再生受损或患病的骨骼，因为它们能够刺激骨骼生长。这种能力与在玻璃表面上形成与骨结合的羟基磷灰石层以及在体液中释放可溶性二氧化硅和钙离子加速骨生长有关。银离子的加入由于抗菌Ag+离子的释放而赋予玻璃以抗菌性能。因此，抗菌活性与玻璃的溶解性能密切相关，而玻璃的溶解性能又与其原子级结构有关。因此，为了研究和控制玻璃的抗菌性能，在原子水平上对玻璃的结构表征是必不可少的。用中子衍射法研究了不同Ag_2O含量（0、2、4、6mol%）的含银钙硅溶胶-凝胶生物活性玻璃的结构。银的存在对主体玻璃结构几乎没有影响，尽管存在一些银金属纳米颗粒。结果与以前的计算机模拟一致。
Bioactive sol-gel calcia-silica glasses can regenerate damaged or diseased bones due to their ability to stimulate bone growth. This capability is related to the formation of a hydroxyapatite layer on the glass surface, which bonds with bone, and the release of soluble silica and calcium ions in the body fluid which accelerates bone growth. The addition of silver ions imbues the glass with antibacterial properties due to the release of antibacterial Ag+ ion. The antibacterial activity is therefore closely dependent on the dissolution properties of the glasses which in turn are related to their atomic-level structure. Structural characterisation of the glasses at the atomic level is therefore essential in order to investigate and control the antibacterial properties of the glass. We have used neutron diffraction to investigate the structure of silver-containing calcia-silica sol-gel bioactive glasses with different Ag2O loading (0, 2, 4, 6 mol %). The presence of the silver had little effect on the host glass structure, although some silver metal nanoparticles were present. Results agreed with previous computer simulations.