THE ROLE OF H-2-ANTIGENS AND NON-H-2 ANTIGENS AND GENES IN THE REJECTION OF MURINE CARDIAC ALLOGRAFTS
THE ROLE OF H-2-ANTIGENS AND NON-H-2 ANTIGENS AND GENES IN THE REJECTION OF MURINE CARDIAC ALLOGRAFTS
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DOI：
10.1007/bf00376519
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发表时间：
1986-01-01
期刊：
影响因子：
3.2
通讯作者：
MORRIS, PJ
中科院分区：
文献类型：
--
作者：
PEUGH, WN;SUPERINA, RA;MORRIS, PJ
小鼠中的主要组织相容性复合体（MHC）的基因（H-2复合体）已被证明是决定各种品系的小鼠对分离的抗原（例如，溶菌酶）。MHC基因在控制小鼠对多种同种异体抗原的反应性中的作用还不太明确，尽管非MHC基因已被证明在决定某些系统（例如半抗原）的反应性中是重要的，但它们尚未被证明影响血管化器官同种异体移植物的排斥。在这项研究中，小鼠血管化的心脏同种异体移植物的反应性移植在明确的主要（H-2）和次要（非H-2）组织相容性障碍进行了研究，使用同类小鼠在32个不同的供体/受体组合。结果表明，H-2和非H-2基因产物均可作为排斥反应的靶抗原。在应答者水平，它们可以相互作用以影响受体菌株对多种同种异体抗原的应答性。在本研究中，没有发现任何一个基因或一组基因赋予普遍的高或低应答状态。
Genes of the major histocompatibility complex (MHC) in the mouse (H-2 complex) have been shown to be an important factor in determining the immune responsiveness of various strains of mice to isolated antigens (e.g., lysozyme). The role of MHC genes in controlling the responsiveness of mice to multiple alloantigens is less well-defined, and although non-MHC genes have been shown to be important in determining responsiveness in some systems (e.g, haptens), they have not been demonstrated as yet to influence the rejection of vascularized organ allografts. In this study, the responsiveness of mice to vascularized cardiac allografts transplanted across well-defined major (H-2) and minor (non-H-2) histocompatibility barriers was investigated using congenic mice in 32 different donor/recipient combinations. The results show that both H-2 and non-H-2 gene products can act as target alloantigens for rejection. At the responder level, they may interact to effect responsiveness of a recipient strain to multiple alloantigens. In no case in this study has any one gene or group of genes been found to confer universal high or low responder status.