Mixed matrix hollow fiber membranes for removal of protein-bound toxins from human plasma
Mixed matrix hollow fiber membranes for removal of protein-bound toxins from human plasma
复制标题
用于去除人血浆中蛋白质结合毒素的混合基质中空纤维膜
DOI：
10.1016/j.biomaterials.2013.07.008
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发表时间：
2013-10-01
期刊：
影响因子：
14
通讯作者：
Stamatialis, Dimitrios
中科院分区：
文献类型：
--
作者：
Tijink, Marlon S. L.;Wester, Maarten;Stamatialis, Dimitrios
In end stage renal disease (ESRD) waste solutes accumulate in body fluid. Removal of protein bound solutes using conventional renal replacement therapies is currently very poor while their accumulation is associated with adverse outcomes in ESRD. Here we investigate the application of a hollow fiber mixed matrix membrane (MMM) for removal of these toxins. The MMM hollow fiber consists of porous macro-void free polymeric inner membrane layer well attached to the activated carbon containing outer MMM layer. The new membranes have permeation properties in the ultrafiltration range. Under static conditions, they adsorb 57% p-cresylsulfate, 82% indoxyl sulfate and 94% of hippuric acid from spiked human plasma in 4 h. Under dynamic conditions, they adsorb on average 2.27 mg PCS/g membrane and 3.58 mg IS/g membrane in 4 h in diffusion experiments and 2.68 mg/g membrane PCS and 12.85 mg/g membrane IS in convection experiments. Based on the dynamic experiments we estimate that our membranes would suffice to remove the daily production of these protein bound solutes. (C) 2013 Elsevier Ltd. All rights reserved.
