Wide-field spectral-domain optical coherence tomography in patients and carriers of X-linked retinoschisis.
Wide-field spectral-domain optical coherence tomography in patients and carriers of X-linked retinoschisis.
复制标题
DOI：
10.1016/j.ophtha.2012.07.051
复制
发表时间：
2013-01
期刊：
影响因子：
13.7
通讯作者：
Aroucha PR
中科院分区：
文献类型：
--
作者：
Gregori NZ;Lam BL;Gregori G;Ranganathan S;Stone EM;Morante A;Abukhalil F;Aroucha PR
利用宽视场谱域光学相干断层扫描 (SD-OCT) 成像技术评估 X 连锁视网膜劈裂 (XLRS) 患者和携带者的黄斑和黄斑外视网膜解剖结构。病例系列 六名 XLRS 受影响的男性携带者和三名 XLRS 女性携带者。受试者前瞻性地接受了 XLRS DNA 基因分型和全面的眼科检查，包括视力、30-2 Humphrey 视野、眼底摄影和宽视场 SD-OCT（一种蒙太奇技术，用于生成后极水平约 50°、垂直约 35° 的 SD-OCT 图像）。劈裂空洞的分布和位置 在受影响的 XLRS 男性中，使用蒙太奇 SD-OCT 成像的所有眼睛（11 只眼睛）均观察到不对称的双侧劈裂。宽视场 OCT 图像显示，6 只眼（55%）仅在黄斑中央存在裂隙，3 只眼（27%）在整个黄斑区延伸至颞弓外侧，2 只眼（18%）在整个黄斑区延伸鼻腔至视神经。导致黄斑分裂的囊样间隙存在于所有 11 只眼睛的内核层 (INL) 中，以及 4 只眼睛的外核层 (ONL) 中。 4只眼的神经节细胞层和/或神经纤维层（GCL/NFL）中央凹旁可见一些小囊肿。亚临床黄斑外裂隙（n=5 只眼）见于 INL 内 1 只眼，ONL 内 1 只眼，INL/GCL/NFL 1 只眼，ONL/GCL/NFL 1 只眼，INL/ONL/GCL/NFL 内 1 只眼。鼻侧至视神经（2只眼）很少见到分裂。 9只眼出现中央/旁中央视野缺损。女性携带者在检查或 OCT 中未表现出分裂。广域 SD-OCT 是评估复杂视网膜解剖结构的有用工具。在 XLRS 患者中，黄斑中心凹分裂最常见于 INL。 45% 的眼睛出现亚临床黄斑外裂，并且在 INL、ONL 和 GCL/FNL 中同样普遍。 GCL/FNL 囊样间隙非常小，仅在中央凹和拱廊附近可见。载体无分裂。
To evaluate macular and extramacular retinal anatomy in patients and carriers of X-linked retinoschisis (XLRS) utilizing a wide-field spectral-domain optical coherence tomography (SD-OCT) imaging technique. Case series Six XLRS affected males and three XLRS female carriers. The subjects prospectively underwent XLRS DNA genotyping and comprehensive ophthalmic examination including Visual acuity, 30-2 Humphrey visual field, fundus photography, and wide-field SD-OCT, a montage technique to generate SD-OCT images spanning approximately 50° horizontally and 35° vertically of the posterior pole. distribution and location of schisis cavities Among affected XLRS males, asymmetric bilateral schisis was seen in all eyes imaged with montage SD-OCT (11 eyes). Wide-field OCT images demonstrated schisis cavities only in the central macula in 6 eyes (55%), throughout the macula extending to the outside of the temporal arcades in 3 eyes (27%), and throughout the macula extending nasal to the optic nerve in 2 eyes (18%). Cystoid spaces accounting for macular splitting were present in the inner nuclear layer (INL) in all 11 eyes and also in the outer nuclear layer (ONL) in 4 eyes. A few small cysts were seen parafoveally in the ganglion cell layer and/or nerve fiber layer (GCL/NFL) in 4 eyes. Subclinical extramacular schisis spaces were seen (n=5 eyes) within the INL in 1 eye, ONL in 1 eye, INL/GCL/NFL in 1 eye, ONL/GCL/NFL in 1 eye, and in the INL/ONL/GCL/NFL in 1 eye. Schisis was rarely seen nasal to the optic nerve (2 eyes). Central/paracentral visual field defects were seen in 9 eyes. Female carriers did not show schisis on exam or OCT. Wide-field SD-OCT is a useful tool for evaluating complex retinal anatomy. In XLRS patients, the foveomacular schisis was seen most frequently in the INL. Subclinical extramacular schisis was seen in 45% eyes and was equally prevalent in the INL, ONL, and GCL/FNL. GCL/FNL cystoid spaces were very small and were seen near the fovea and the arcades only. Carriers were schisis-free.
登录
查看更多内容
影响因子：
--
作者：
Gao, H;Kusumi, R;Yung, CW
通讯作者：
Yung, CW
影响因子：
--
作者：
Gerth, Christina;Zawadzki, Robert J.;Heon, Elise
通讯作者：
Heon, Elise
影响因子：
4.4
作者：
Takada, Y;Fariss, RN;Sieving, PA
通讯作者：
Sieving, PA
影响因子：
5.1
作者：
通讯作者：
--
影响因子：
4.4
作者：
Zeng, Y;Takada, Y;Sieving, PA
通讯作者：
Sieving, PA