IMPLANT SITE INFECTION-RATES WITH POROUS AND DENSE MATERIALS
IMPLANT SITE INFECTION-RATES WITH POROUS AND DENSE MATERIALS
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DOI：
10.1002/jbm.820130111
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发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
BROWN, SA
中科院分区：
文献类型：
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作者：
MERRITT, K;SHAFER, JW;BROWN, SA
在小鼠身上研究了带有多孔和致密植入物的植入部位的感染率。在第一个模型（急性感染）中，小鼠皮下注射金黄色葡萄球菌。在植入时的植入部位。在第二个（慢性）模型中，将植入物留在原处 4 周以进行封装或侵入，然后接种生物体。在急性模型中，多孔材料的感染率更高。在组织侵入后的慢性模型中，致密材料的感染率更高。如果微生物在组织侵入之前进入植入物的孔隙，则它们可能可以逃避宿主的防御机制，但一旦植入物被宿主组织侵入，细菌就不太容易建立感染。
The infection rate of implant sites bearing porous and dense implants was studied in mice. In the 1st model (acute infection) the mice were injected with Staphylococcus aureus s.c. at the implant site at the time of implantation. In the 2nd (chronic) model the implants were left in place for 4 wk for encapsulation or invasive to occur and then the organisms were inoculated. In the acute model the infection rate with the porous materials was greater. In the chronic model after tissue invasion the infection rate with the dense materials was greater. Microorganisms probably can evade host defense mechanisms if they enter the pores of the implant before tissue invasion, but once the implant is invaded with host tissue the bacteria are less apt to establish infection.