Therapeutic potential of gel-based injectables for vocal fold regeneration
Therapeutic potential of gel-based injectables for vocal fold regeneration
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DOI：
10.1088/1748-6041/7/2/024103
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发表时间：
2012-04-01
影响因子：
4
通讯作者：
Prestwich, Glenn D.
中科院分区：
文献类型：
--
作者：
Bartlett, Rebecca S.;Thibeault, Susan L.;Prestwich, Glenn D.
声带在解剖学和生物力学上是独特的，因此使修复和再生的组织工程策略的设计和实施变得复杂。对组织生物力学、伤口愈合动力学和创新的凝胶疗法的深入理解的整合产生了对声带瘢痕的有效治疗在几年内可以在临床上实现的概念的热情。成纤维细胞表型和基因表达是由损伤部位的三维机械和化学微环境介导的。因此，治疗方法需要协调受伤的声带组织中伤口愈合反应的空间和时间方面，以实现最佳的临床结果。成功的基于凝胶的注射剂用于声带瘢痕形成将需要敏锐地理解天然炎症反应如何启动后期细胞外基质重塑，这反过来将决定组织的最终生物力学特性。我们概述了与这种翻译相关的挑战以及提出的基于凝胶的注射液。
Vocal folds are anatomically and biomechanically unique, thus complicating the design and implementation of tissue engineering strategies for repair and regeneration. Integration of an enhanced understanding of tissue biomechanics, wound healing dynamics and innovative gel-based therapeutics has generated enthusiasm for the notion that an efficacious treatment for vocal fold scarring could be clinically attainable within several years. Fibroblast phenotype and gene expression are mediated by the three-dimensional mechanical and chemical microenvironment at an injury site. Thus, therapeutic approaches need to coordinate spatial and temporal aspects of the wound healing response in an injured vocal tissue to achieve an optimal clinical outcome. Successful gel-based injectables for vocal fold scarring will require a keen understanding of how the native inflammatory response sets into motion the later extracellular matrix remodeling, which in turn will determine the ultimate biomechanical properties of the tissue. We present an overview of the challenges associated with this translation as well as the proposed gel-based injectable solutions.