The Role of Emerin in Cancer Progression and Metastasis.
The Role of Emerin in Cancer Progression and Metastasis.
复制标题
Emerin在癌症进展和转移中的作用。
DOI：
10.3390/ijms222011289
复制
发表时间：
2021-10-19
影响因子：
5.6
通讯作者：
Holaska JM
中科院分区：
文献类型：
--
作者：
Liddane AG;Holaska JM
本领域普遍认识到，癌细胞表现出其细胞核的大小和形状的变化。这些特征通常在癌症患者的诊断和预后中作为重要的生物标志物。细胞核的大小可以显着影响细胞迁移，因为它的尺寸非常大。预测核结构变化调节癌细胞迁移。核异常在广泛的癌症类型中是常见的，无论组织来源、突变谱和信号依赖性如何。核改变的普遍性表明，核结构的变化可能与转化过程密切相关。驱动这些核异常的因素及其功能后果尚未完全了解。核被膜蛋白在调节肿瘤细胞核的大小和结构中起着重要的作用。在许多癌症中发现核纤层蛋白（包括Emerin）的表达改变，并且这种表达与更好的临床结果相关。一种模型正在出现，其中emerin以及其他核纤层蛋白结合到核骨架调节核结构以影响转移。在该模型中，emerin和核纤层蛋白在转移性转化中起核心作用，因为转化过程中emerin表达降低导致细胞迁移、内渗和外渗增加所需的核结构缺陷。在此，我们讨论了核纤层蛋白的细胞功能，特别关注emerin，以及这些功能如何影响癌症的进展和转移。
It is commonly recognized in the field that cancer cells exhibit changes in the size and shape of their nuclei. These features often serve as important biomarkers in the diagnosis and prognosis of cancer patients. Nuclear size can significantly impact cell migration due to its incredibly large size. Nuclear structural changes are predicted to regulate cancer cell migration. Nuclear abnormalities are common across a vast spectrum of cancer types, regardless of tissue source, mutational spectrum, and signaling dependencies. The pervasiveness of nuclear alterations suggests that changes in nuclear structure may be crucially linked to the transformation process. The factors driving these nuclear abnormalities, and the functional consequences, are not completely understood. Nuclear envelope proteins play an important role in regulating nuclear size and structure in cancer. Altered expression of nuclear lamina proteins, including emerin, is found in many cancers and this expression is correlated with better clinical outcomes. A model is emerging whereby emerin, as well as other nuclear lamina proteins, binding to the nucleoskeleton regulates the nuclear structure to impact metastasis. In this model, emerin and lamins play a central role in metastatic transformation, since decreased emerin expression during transformation causes the nuclear structural defects required for increased cell migration, intravasation, and extravasation. Herein, we discuss the cellular functions of nuclear lamina proteins, with a particular focus on emerin, and how these functions impact cancer progression and metastasis.
登录
查看更多内容
DOI：
10.1007/978-1-4899-8032-8_5
发表时间：
2014-01-01
期刊：
CANCER BIOLOGY AND THE NUCLEAR ENVELOPE: RECENT ADVANCES MAY ELUCIDATE PAST PARADOXES
影响因子：
--
作者：
Bussolati, Gianni;Maletta, Francesca;Marchio, Caterina
通讯作者：
Marchio, Caterina
影响因子：
11.4
作者：
Cai, ML;Huang, Y;Clore, GM
通讯作者：
Clore, GM
影响因子：
3.5
作者：
Arimura, T;Helbling-Leclerc, A;Bonne, G
通讯作者：
Bonne, G
影响因子：
8.4
作者：
Belt, E. J. Th.;Fijneman, R. J. A.;Meijer, G. A.
通讯作者：
Meijer, G. A.
影响因子：
4
作者：
Berk, Jason M.;Simon, Dan N.;Wilson, Katherine L.
通讯作者：
Wilson, Katherine L.