A Phase II trial of induction Cisplatin, 5-FU, Leucovorin, and Interferon α-2B (PFL-α) followed by concurrent Hydroxyurea, 5-FU and radiation for Stage IV squamous cell cancers of the head and neck (HNC)
A Phase II trial of induction Cisplatin, 5-FU, Leucovorin, and Interferon α-2B (PFL-α) followed by concurrent Hydroxyurea, 5-FU and radiation for Stage IV squamous cell cancers of the head and neck (HNC)
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诱导顺铂、5-FU、亚叶酸和干扰素 α-2B (PFL-α)，随后同时使用羟基脲、5-FU 和放射治疗 IV 期头颈鳞状细胞癌 (HNC) 的 II 期试验
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
E. Yokes
中科院分区：
文献类型：
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作者：
M. Kies;D. Haraf;B. Mittal;I. Athanasiadis;M. Kozloff;J. McEvilly;R. Mick;W. Moran;W. Panje;H. Pelzer;T. D. Sheehan;R. Weichselbaum;B. Wenig;E. Yokes
顺铂和输注氟尿嘧啶的联合治疗已广泛用于治疗局部晚期鳞状头颈癌的诊断和复发[1-4]。当应用于新辅助治疗时，它导致了高缓解率，并可能降低了远处转移的发生率。然而，尚未证明总生存期增加，因此该药物组合的使用仍在主要管理中进行研究[5，6]。
The combination of Cisplatin and Infusional fluorouracil has been widely used for the treatment of locally advanced squamous head and neck cancer, at diagnosis and recurrence [1–4]. When applied in the Neo-Adjuvant setting, it has resulted in high response rates and probably a reduced incidence of distant metastases. Overall survival, however, has not been proven to be increased and therefore use of this drug combination remains investigational in primary management [5, 6).
培养的结肠腺癌细胞中 5-氟尿嘧啶、[6RS]甲酰四氢叶酸和重组人干扰素-α 2a 之间的相互作用。
影响因子：
16.2
作者：
Houghton,JA;Adkins,DA;Rahman,A;Houghton,PJ
通讯作者：
Houghton,PJ