Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer
Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer
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DOI：
10.1016/s0169-5002(00)00225-7
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发表时间：
2001-05-01
期刊：
影响因子：
5.3
通讯作者：
Gorgoulis, V
中科院分区：
文献类型：
--
作者：
Vassilakopoulos, T;Troupis, T;Gorgoulis, V
鳞状细胞癌抗原(SCC-Ag)是非小细胞肺癌(NSCLC)分泌的一种糖蛋白。本研究探讨鳞癌抗原在非小细胞肺癌中的诊断和预后意义。采用受试者工作特征(ROC)曲线分析方法，对100例非小细胞肺癌手术患者和50例APE配对的健康对照进行SCC-Ag诊断，并确定最佳阈值。这一阈值随后在53名患者和49名健康对照组中进行了前瞻性验证。采用单因素和多因素比例风险模型检验SCC-Ag水平及其术后下降对预后的意义。ROC曲线下面积为0.71+/-0.04，最佳分界值为1.4 ng/ml，用于鉴别验证组患者，灵敏度为0.55，特异度为1.0。术后鳞癌抗原下降的风险比为0.144(95%CI 0.074~0.281)，术前鳞癌抗原水平的风险比为5.823(3.299~10.278)。多因素分析显示，只有疾病分期和患者年龄是影响预后的重要因素。结论：血清SCC-Ag水平对非小细胞肺癌有中度诊断作用。术前SCC-Ag水平和术后SCC-Ag下降均有预后意义，但不如疾病分期和患者年龄。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Squamous cell carcinoma antigen (SCC-Ag) is a glycoprotein secreted by non small cell lung tumours (NSCLC). This study investigated the diagnostic and prognostic significance of SCC-Ag in NSCLC. Receiver operating characteristic (ROC) curve analysis was used to test the diagnostic performance of the SCC-Ag and determine the optimal threshold value in a group of 100 NSCLC patients undergoing surgery and 50 ape matched healthy controls. This threshold was then prospectively validated in a group of 53 patients and 49 healthy controls. The prognostic significance of the preoperative SCC-Ag level and its postoperative decrease were tested using univariate and multivariate proportional hazard models. The area under the ROC curve was 0.71 +/- 0.04, and the best cutoff value was 1.4 ng/ml. This discriminated patients in the validation group, with a sensitivity of 0.55 and a specificity of 1.0. The hazard ratio was 0.144 (95% CI 0.074-0.281) for the postoperative decrease in the SCC Ag, and 5.823 (3.299-10.278) for the preoperative SCC Ag level. Multivariate analysis revealed that only disease stage and patients' age are strong prognostic factors for survival. In conclusion, the SCC-Ag serum level has moderate diagnostic role in NSCLC. Both the preoperative:SCC-Ag level and its postoperative decrease have prognostic significance, yet inferior to the disease stage and the patient's age. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.