EFFECT OF PREGNANCY ON THE PHARMACOKINETICS OF CAFFEINE
EFFECT OF PREGNANCY ON THE PHARMACOKINETICS OF CAFFEINE
复制标题
DOI：
10.1007/bf00637512
复制
发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
SCHLATTER, C
中科院分区：
文献类型：
--
作者：
KNUTTI, R;ROTHWEILER, H;SCHLATTER, C
Individual variation in the half-life of caffeine in the body was measured by HPLC [high pressure liquid chromatography] analysis of saliva samples. The mean for adult males and non-pregnant females was 3.4 h (range 2-5 h, n = 25), and 8.3 h (range 3-16 h, n = 57) for pregnant women. After delivery, in most cases the values returned to normal within 1 mo. The individual values could not be correlated with age, weight or coffee consumption. Women drinking large quantities of coffee should be aware of the side effects of coffee during pregnancy, as they may occur at a lower rate of consumption than in the non-pregnant state.
