Evidence of placental abruption as a chronic process: Associations with vaginal bleeding early in pregnancy and placental lesions
Evidence of placental abruption as a chronic process: Associations with vaginal bleeding early in pregnancy and placental lesions
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DOI：
10.1016/j.ejogrb.2006.01.016
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发表时间：
2006-09-01
期刊：
影响因子：
--
通讯作者：
Smulian, John C.
中科院分区：
文献类型：
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作者：
Ananth, Cande V.;Oyelese, Yinka;Smulian, John C.
背景资料：临床医生广泛认为胎盘脱垂是一种急性事件，尽管越来越多的数据表明胎盘脱垂是妊娠早期慢性过程的最终结果，甚至可能延伸到受孕。围产期协作计划是一项前瞻性队列研究，于1959年至1966年在美国进行。由于登记妊娠的管理没有现代围产期监测和干预造成的偏见，这些数据中的疾病自然史是研究产科并发症如胎盘早剥的理想方法。目的：我们评估早期妊娠阴道出血的临床特征和组织学病变的相关性和贡献研究设计：采用围产期协作计划（1959-1966）中登记的妇女，分析仅限于单胎分娩的妇女（n = 46，364）。比较了有和无阴道出血的妇女之间胎盘脱垂的风险，
Background: Clinicians widely regard placental abruption as an acute event, though accumulating data point towards abruption being the end-result of chronic processes early in pregnancy, and perhaps even extending to conception. The Collaborative Perinatal Project was a prospective cohort study performed from 1959 to 1966 in the United States. Since enrolled pregnancies were managed without the biases created by modem perinatal surveillance and interventions, the natural history of disease in these data is ideal to study obstetrical complications such as placental abruption.Objective: We assessed the associations versus contributions of the clinical feature of early gestational vaginal bleeding and histologic lesions (chronic and acute) with placental abruption.Study design: Women enrolled in the Collaborative Perinatal Project (1959-1966) were used, restricting the analysis to those that delivered singleton births (n = 46,364). Risks of placental abruption were compared between women with and without vaginal bleeding at