Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes.
Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes.
复制标题
基于病毒诱导的淋巴结归巢和归巢诱导的 CD4 淋巴细胞凋亡的 HIV-1 疾病进展模型。
DOI：
10.1097/00126334-200008010-00010
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Cloyd,M
中科院分区：
文献类型：
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作者：
Kirschner,D;Webb,GF;Cloyd,M
几个提出的理论描述了艾滋病毒感染的进程。即便如此，也没有具体证据支持任何全面的证据，包括，例如，为什么在平均10年的时间里，CD4+T细胞计数从血液中的1000个/立方米下降到大约100个/立方米，而伴随而来的病毒载量相对稳定，在晚期疾病中增加了几个数量级。在这里，我们开发并验证了一个理论模型，该模型可以解释HIV-1疾病进展的许多方面，该模型可以解释HIV-1疾病进展的许多方面，该模型由于HIV诱导的淋巴结归巢增强和随后静止的CD4+T细胞的凋亡而改变了淋巴系统和血液之间的淋巴细胞循环模式。这些结果导致了在高效抗逆转录病毒治疗期间重新计算CD4+淋巴细胞动力学，并为治疗提供了新的靶点。
Several proposed theories have described the progression of HIV infection. Even so, no concrete evidence supports any as comprehensive, including, for example, why the CD4+ T-cell counts fall from 1000/mm 3 of blood to roughly 100/mm 3 over an average 10-year period, whereas concomitant viral loads are relatively constant, increasing by several orders of magnitude in late-stage disease. Here, we develop and validate a theoretical model that altered lymphocyte circulation patterns between the lymph system and blood due to HIV-induced enhanced lymph-node homing and subsequent apoptosis of resting CD4+ T cells can explain many aspects of HIV-1 disease progression. These results lead to a recalculation of the CD4+ lymphocyte dynamics during highly active antiretroviral therapy, and also suggest new targets for therapy.