Effect of vitamin D deficiency on the development of postoperative atrial fibrillation in coronary artery bypass patients.
Effect of vitamin D deficiency on the development of postoperative atrial fibrillation in coronary artery bypass patients.
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DOI：
10.15171/jcvtr.2016.29
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发表时间：
2016
影响因子：
1.1
通讯作者：
Yeniterzi M
中科院分区：
文献类型：
--
作者：
Gode S;Aksu T;Demirel A;Sunbul M;Gul M;Bakır I;Yeniterzi M
前言：冠状动脉旁路移植术(CABG)患者术后房颤(POAF)的发生可能与多种因素有关。在我们的研究中，我们证实了维生素D缺乏对POAF发生的影响。方法：在这项前瞻性病例对照研究中，研究对象为接受选择性、孤立冠状动脉搭桥术的患者。共有15名患者(16.6%)在术后前5天内发生POAF，构成POAF组。75例同期有窦性心律的患者为非POAF组。两组在实验室、临床、超声心动图、手术和术后参数方面进行了统计学比较。结果：所有患者出院时均为窦性心律。研究组的基线特征具有可比性。观察组维生素D水平低于非观察组(分别为9·0±5·0和15·0±8·4 ng/mL，P=0.007)。POAF组患者左房内径和高血压发生率均高于非POAF组。结论：维生素D缺乏或缺乏患者的POAF发生率明显高于维生素D水平在正常范围的患者。因此，维生素D缺乏或不足可能是CABG患者发生POAF的一个预测因素。
Introduction: Various factors may be responsible for the development of postoperative atrial fibrillation (POAF) in coronary artery bypass graft (CABG) patients. In our study, we demonstrated the effect of vitamin D deficiency on the development of POAF. Methods: In this prospective case control study, patients undergoing elective, isolated CABG were considered. A total of 15 patients (16.6%) who developed POAF during the first five days after surgery made up the POAF group. Seventy-five patients that had a sinus rhythm in the same period were the non-POAF group. The two groups were compared statistically in terms of laboratory, clinical, echocardiographic, operative, and postoperative parameters. Results: All patients were in sinus rhythm at discharge. The baseline characteristics of the study groups were comparable. The POAF group had a lower vitamin D level than the non-POAF group (9.0 ± 5.0 and 15.0 ± 8.4 ng/mL, respectively; P=0.007). In the POAF group, the patients’ left atrium diameter and incidence of hypertension (HT) were higher than those of the non-POAF group. Conclusion: Incidence of POAF was significantly higher in patients with vitamin D deficiency or insufficiency than the patients with vitamin D level in normal range. Therefore vitamin D deficiency or insufficiency may be a predictor of POAF in patients with CABG.