Calcium and vitamin D intake influence bone mass, but not short-term fracture risk, in Caucasian postmenopausal women from the National Osteoporosis Risk Assessment (NORA) study
Calcium and vitamin D intake influence bone mass, but not short-term fracture risk, in Caucasian postmenopausal women from the National Osteoporosis Risk Assessment (NORA) study
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DOI：
10.1007/s00198-007-0501-2
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发表时间：
2008-05-01
影响因子：
4
通讯作者：
Chen, Y. T.
中科院分区：
文献类型：
--
作者：
Nieves, J. W.;Barrett-Connor, E.;Chen, Y. T.
对76,507名绝经后高加索妇女进行了钙和维生素D摄入对骨密度和一年骨折风险的影响评估。在这些白人女性中，无论是否摄入维生素D，充足的钙都能显著降低骨质疏松症的几率，但不会降低骨折的风险。钙和维生素D的摄入可能对骨骼健康很重要；然而，研究产生了不同的结果。方法对76,507名绝经后高加索妇女进行了钙和维生素D摄入对骨密度（BMD）和一年内骨折发生率的影响评估，这些妇女完成了一份饮食问卷，包括儿童、成人和目前的乳制品消费。目前的维生素D摄入量是通过牛奶、鱼、补充剂和阳光照射来计算的。测量前臂、手指或脚后跟的骨密度。大约3年后，36209名参与者返回了一份关于新骨折的问卷。钙和维生素D对骨质疏松和骨折风险的影响通过多协变量调整后的logistic回归进行评估。结果终生较高的钙摄入量与骨质疏松症（外周骨密度t评分）发生率降低相关
The impact of calcium and vitamin D intake on bone density and one-year fracture risk was assessed in 76,507 postmenopausal Caucasian women. Adequate calcium with or without vitamin D significantly reduced the odds of osteoporosis but not the risk of fracture in these Caucasian women.Introduction Calcium and vitamin D intake may be important for bone health; however, studies have produced mixed results.Methods The impact of calcium and vitamin D intake on bone mineral density (BMD) and one-year fracture incidence was assessed in 76,507 postmenopausal Caucasian women who completed a dietary questionnaire that included childhood, adult, and current consumption of dairy products. Current vitamin D intake was calculated from milk, fish, supplements and sunlight exposure. BMD was measured at the forearm, finger or heel. Approximately 3 years later, 36,209 participants returned a questionnaire about new fractures. The impact of calcium and vitamin D on risk of osteoporosis and fracture was evaluated by logistic regression adjusted for multiple covariates.Results Higher lifetime calcium intake was associated with reduced odds of osteoporosis (peripheral BMD T-score