Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study.
Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study.
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青少年抑制控制和物质使用脆弱性的发展：一项纵向神经影像学研究。
DOI：
10.1016/j.dcn.2020.100771
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发表时间：
2020
影响因子：
4.7
通讯作者：
Luna,Beatriz
中科院分区：
文献类型：
--
作者：
Quach,Alina;Tervo-Clemmens,Brenden;Foran,William;Calabro,FinneganJ;Chung,Tammy;Clark,DuncanB;Luna,Beatriz
先前的研究表明，物质使用的风险与抑制控制不良有关。然而，目前尚不清楚高危青少年是否遵循不同的抑制控制发展模式。作为国家青少年神经发育和酒精联盟纵向研究的一部分，参与者（N = 113，基线年龄：12-21）在 fMRI 期间完成了一项奖励性抗眼跳任务，最多有三个时间点。我们研究了物质使用风险因素，包括精神病理学（外化、内化）和物质使用障碍家族史，是否与抑制控制表现和 BOLD 激活的发育差异相关。在所检查的物质使用危险因素中，只有外化精神病理学表现出抑制控制表现的发育差异，其中较高的分数与青春期早期较低的正确反应率（p = .013）和较短的潜伏期（p < .001）相关，并在青春期后期正常化。神经影像学结果显示，较高的外化评分与左侧额中回发育稳定的低激活有关（p < .05 已校正），但后顶叶皮层激活的发育模式存在差异（p < .05 已校正）。这些发现表明，青春期早期可能是一个通过认知和表型去抑制而容易遭受药物滥用的独特时期。
Previous research indicates that risk for substance use is associated with poor inhibitory control. However, it remains unclear whether at-risk youth follow divergent patterns of inhibitory control development. As part of the longitudinal National Consortium on Adolescent Neurodevelopment and Alcohol study, participants (N = 113, baseline age: 12–21) completed a rewarded antisaccade task during fMRI, with up to three time points. We examined whether substance use risk factors, including psychopathology (externalizing, internalizing) and family history of substance use disorder, were associated with developmental differences in inhibitory control performance and BOLD activation. Among the examined substance use risk factors, only externalizing psychopathology exhibited developmental differences in inhibitory control performance, where higher scores were associated with lower correct response rates (p = .013) and shorter latencies (p < .001) in early adolescence that normalized by late adolescence. Neuroimaging results revealed higher externalizing scores were associated with developmentally-stable hypo-activation in the left middle frontal gyrus (p < .05 corrected), but divergent developmental patterns of posterior parietal cortex activation (p < .05 corrected). These findings suggest that early adolescence may be a unique period of substance use vulnerability via cognitive and phenotypic disinhibition.