TRYPSIN AND LACTOFERRIN LEVELS IN PURE PANCREATIC-JUICE IN PATIENTS WITH PANCREATIC DISEASE
TRYPSIN AND LACTOFERRIN LEVELS IN PURE PANCREATIC-JUICE IN PATIENTS WITH PANCREATIC DISEASE
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DOI：
10.1136/gut.20.11.983
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发表时间：
1979-01-01
期刊：
影响因子：
24.5
通讯作者：
READ, AE
中科院分区：
文献类型：
--
作者：
FEDAIL, SS;HARVEY, RF;READ, AE
从44例疑似胰腺疾病患者的纯胰液中检测免疫反应性胰蛋白酶水平。胰腺癌患者均具有低胰蛋白酶浓度（中值3.6 μ g/ml，范围0.6-12.0），但慢性胰腺炎患者具有非常可变的水平（中值14.2 μ g/ml，范围3.2-76.8），显示与无胰腺疾病的患者（中值37.1 μ g/ml，范围10.4-66.0）相当大的重叠。当测量胰液中的乳铁蛋白水平时，所有患有慢性胰腺炎的患者的水平（均大于900 ng/ml）比对照受试者或患有胰腺癌的患者（均小于400 ng/ml）高得多。胰蛋白酶和乳铁蛋白在纯胰液的联合测量似乎是更有前途的比任何其他目前可用的测试与慢性胰腺炎的胰腺癌患者的分离。
Levels of immunoreactive trypsin were measured in pure pancreatic juice obtained endoscopically from 44 patients with suspected pancreatic disease. Patients with pancreatic cancer all had low trypsin concentrations (median 3.6 .mu.g/ml, range 0.6-12.0), but those with chronic pancreatitis had very variable levels (median 14.2 .mu.g/ml, range 3.2-76.8), showing a considerable overlap with patients without pancreatic disease (median 37.1 .mu.g/ml, range 10.4-66.0). When levels of lactoferrin in pancreatic juice were measured, all patients with chronic pancreatitis had much higher levels (all greater than 900 ng/ml) than control subjects or patients with pancreatic cancer (all less than 400 ng/ml). The combined measurement of trypsin and lactoferrin in pure pancreatic juice appeared to be more promising than any other currently available test for the separation of patients with pancreatic cancer from those with chronic pancreatitis.