Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice
Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice
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第二代抗精神病药齐拉西酮影响小鼠核心时钟基因 mRNA 表达
DOI：
10.1016/j.jphs.2020.06.005
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发表时间：
2020
影响因子：
3.5
通讯作者：
Nishimura Katsuji
中科院分区：
文献类型：
--
作者：
Moriya Shunpei;Takahashi Hitoshi;Masukawa Daiki;Yamada Makiko;Ishigooka Jun;Nishimura Katsuji
一些精神疾病与生物钟系统的紊乱有关。齐拉西酮(Ziprasidone，ZIP)是第二代抗精神病药物，广泛用于精神病学相关的药物治疗，但其作用机制尚不清楚。我们测量了ZIP处理的小鼠海马区和杏仁体中时钟基因的波动模式。关灯(ZT14)后2小时，ZIP显著增加大鼠海马区Per1、PER2和BMal1mRNA的表达，而杏仁核则无明显变化。这些结果提示，ZIP可能影响时钟基因的调节，这可能代表了症状改善的潜在途径。
Some psychiatric diseases are associated with disruptions in the circadian clock system. Ziprasidone (ZIP), a second-generation antipsychotic, is widely used for psychiatry-related pharmacotherapy but its mechanism has not been clearly elucidated. We measured clock gene fluctuation patterns in the hippocampus and the amygdala in ZIP-treated mice. ZIP significantly increasedPer1,Per2, andBmal1mRNA 2 h after the lights were turned off (ZT14) in the hippocampus, but not in the amygdala. These results suggest that ZIP might affect clock gene regulation, which could represent the pathway underlying symptom amelioration.