Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy
Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy
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DOI：
10.1021/nl080496z
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发表时间：
2008-05-01
期刊：
影响因子：
10.8
通讯作者：
Krishnan, Sunil
中科院分区：
文献类型：
--
作者：
Diagaradjane, Parmeswaran;Shetty, Anil;Krishnan, Sunil
我们报告了使用金纳米壳的体内肿瘤辐射反应的非侵入性调制。通过磁共振温度成像非侵入性量化的载金纳米壳肿瘤的近红外照明产生的中温热疗导致肿瘤灌注的早期增加，从而降低肿瘤的缺氧分数。随后的放射剂量诱导血管破裂，伴有广泛的肿瘤坏死。隔离在血管周围空间中的金纳米壳介导这两种肿瘤血管聚焦效应以改善肿瘤的辐射响应。这种新的综合抗缺氧和局部血管破坏疗法可能与其他传统的抗肿瘤疗法相结合。
We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.