FETAL MORTALITY IN ADULT MICE AFTER SUPEROVULATION WITH GONADOTROPHINS
FETAL MORTALITY IN ADULT MICE AFTER SUPEROVULATION WITH GONADOTROPHINS
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DOI：
10.1002/jez.1401410206
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发表时间：
1959-01-01
影响因子：
--
通讯作者：
FOWLER, RE
中科院分区：
文献类型：
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作者：
EDWARDS, RG;FOWLER, RE
在用怀孕母马血清和人绒毛膜促性腺激素治疗的成年小鼠中研究了植入后和分娩时的胎儿死亡率。植入了 3 至 32 个胚胎。在一些接受治疗的小鼠和对照小鼠中，所有胚胎在植入后均死亡。所有胚胎的死亡并不是因为大量胚胎的植入。大多数小鼠在妊娠 18 1/2 天时仍怀有活胎儿。许多小鼠有超过 20 个活胎儿，最高数量为 27 个。妊娠 11 1/2 天前的胎儿死亡率与过度拥挤无关，约占植入胚胎的 16%。 11 1/2 至 18 1/2 天之间的死亡率随着植入胚胎数量的增加而增加，植入 14 个或更多胚胎的女性中有 11.4% 的胎儿死亡。融合胎盘上的死亡胎儿比正常胎盘上更常见。小鼠之间在维持活胎儿至妊娠 11 1/2 天或更早阶段的能力方面发现了异质性。许多胚胎被植入，至妊娠18 1/2 天。在子宫的宫颈部分发现了更多的吸收胚胎，尤其是靠近宫颈的地方，但差异并不明显。拥挤子宫中的活胎儿在妊娠 18 1/2 天时非常小。植入大量胚胎的小鼠在分娩时胎儿死亡率最高，如果雌性体内的胚胎数量超过 19 个，则很少或根本没有胎儿存活。如果植入相同数量的胚胎，治疗小鼠和对照小鼠在分娩时死亡的胎儿比例相似。男性和女性在分娩时的存活率相同。治疗小鼠和对照小鼠的平均产仔数相似。
Fetal mortality after implantation and at parturition were studied in adult mice which had been treated with pregnant mares'' serum and human chorionic gonadotropin. Between 3 and 32 embryos were implanted. In a few treated and control mice, all of the embryos died after implantation. Death of all embryos was not due to the implantation of large numbers of embryos. Most mice carried living fetuses to 18 1/2 days gestation. Many mice had more than 20 living fetuses, the highest number being 27. Fetal mortality before 11 1/2 days gestation was independent of overcrowding and accounted for approximately 16% of the implanted embryos. Mortality between 11 1/2 and 18 1/2 days increased with the numbers of embryos implanted, 11.4% of the fetuses dying in females with 14 or more implanted embryos. Dead fetuses were found more frequently on fused than on normal placentae. Heterogeneity was found between mice in their ability to maintain living fetuses to 11 1/2 days gestation or, especially wher. many embryos were implanted, to 18 1/2 days gestation. More resorbing embryos were found in the cervical half of the uterus, especially next to the cervix, though the difference was not marked. Living fetuses in crowded uteri were extremely small at 18 1/2 days gestation. Fetal mortality at parturition was highest in mice with many implanted embryos, few or no fetuses surviving birth if more than 19 were present in a female. The proportion of fetuses dying at parturition was similar in treated and control mice if the same number of embryos were implanted. Males and females survived parturition equally well. Mean litter size was similar in treated and control mice.