The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles
The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles
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DOI：
10.1016/j.biomaterials.2008.09.020
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发表时间：
2009-01-01
期刊：
影响因子：
14
通讯作者：
Wilson, Michael
中科院分区：
文献类型：
--
作者：
Perni, Stefano;Piccirillo, Clara;Wilson, Michael
我们报告的聚硅氧烷聚合物的形成包含嵌入的亚甲蓝和金纳米粒子纳入膨胀-封装-收缩的方法。这些聚合物对耐甲氧西林金黄色葡萄球菌和大肠杆菌显示出显著的抗微生物活性，当暴露于低功率660 nM激光5分钟时，活菌计数减少高达3.5 log（10）。细菌杀灭是由于光诱导的亚甲基蓝产生单线态氧和其他活性氧物质。有趣的是，2 nM金纳米颗粒的存在显著增强了亚甲蓝杀死细菌的能力。(C)2008爱思唯尔有限公司保留所有权利。
We report the formation of polysiloxane polymers containing embedded methylene blue and gold nanoparticles incorporated by a swell-encapsulation-shrink method. These polymers show significant antimicrobial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with up to a 3.5 log(10) reduction in the viable count when exposed for 5 min to light from a low power 660 nM laser. The bacterial kill is due to the light-induced production of singlet oxygen and other reactive oxygen species by the methylene blue. Interestingly, the presence of 2 nM gold nanoparticles significantly enhanced the ability of the methylene blue to kill bacteria. (C) 2008 Elsevier Ltd. All rights reserved.