Salivary and Serum Antioxidant and Oxidative Stress Markers in Dental Caries
Salivary and Serum Antioxidant and Oxidative Stress Markers in Dental Caries
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DOI：
10.1159/000488213
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发表时间：
2018-01-01
期刊：
影响因子：
4.2
通讯作者：
Darvishi, Mohammad
中科院分区：
文献类型：
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作者：
Ahmadi-Motamayel, Fatemeh;Goodarzi, Mohammad Taghi;Darvishi, Mohammad
龋病是世界上最常见的慢性、非传染性、可预防的口腔疾病。氧化可能在龋病的发生、发展中起重要作用。体液中的抗氧化剂可以保护细胞。本研究的目的是评价龋病患者唾液和血清总抗氧化能力(TAC)和丙二醛(MDA)水平。共有118名健康的无龋齿和有龋齿的男女学生参加。临床检出龋病。采集未受刺激的全唾液样本和血液样本。唾液化学分析采用分光光度法。用STATA 11软件进行t检验。病例组和对照组的唾液和血清TAC水平无显著差异。病例组和对照组唾液丙二醛平均水平分别为0.71+/-0.1和0.35+/-0.06nmol/mL。结果显示，病例组唾液和血清丙二醛水平明显高于健康对照组。与健康对照组相比，龋病组的氧化应激标志物显著升高。抗氧化剂在两组之间没有显著差异。丙二醛可由龋齿产生，导致抗氧化剂水平下降，导致疾病进展。需要进一步的研究来确定丙二醛是这种疾病的原因还是结果。
Dental caries is the most common, chronic, noncommunicable, preventable oral disease worldwide. Oxidation may play an important role in dental caries initiation and progression. Antioxidants in body fluids protect cells. The aim of this study was to evaluate salivary and serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels in dental caries. A total of 118 healthy caries-free and caries-active male and female students participated. Caries was detected clinically. Unstimulated whole-saliva samples and blood samples were obtained. Sialochemical analysis was carried out by spectrophotometric assay. Data were analyzed with the Student t test using STATA 11. Salivary and serum TAC levels in the case and control groups did not show any significant differences. Mean salivary MDA levels in the case and control groups were 0.71 +/- 0.1 and 0.35 +/- 0.06 nmol/mL, respectively. The results showed significantly higher levels of salivary and serum MDA in the case group compared to the healthy control group. The oxidative stress marker was significantly higher in the caries group compared to the healthy control group. Antioxidants were not significantly different between the two groups. MDA can be produced by dental caries, resulting in a decrease in antioxidant levels, causing disease progression. Further studies are necessary to determine whether MDA is the cause or effect of the disease.