EFFECT OF THE NIGROSTRIATAL DOPAMINE SYSTEM ON ACQUIRED NEURAL RESPONSES IN THE STRIATUM OF BEHAVING MONKEYS
EFFECT OF THE NIGROSTRIATAL DOPAMINE SYSTEM ON ACQUIRED NEURAL RESPONSES IN THE STRIATUM OF BEHAVING MONKEYS
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DOI：
10.1126/science.8023166
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发表时间：
1994-07-15
期刊：
影响因子：
56.9
通讯作者：
KIMURA, M
中科院分区：
文献类型：
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作者：
AOSAKI, T;GRAYBIEL, AM;KIMURA, M
黑质纹状体多巴胺系统的功能障碍导致明显的运动障碍，例如帕金森病。在接受经典条件反射任务训练的猴子中，研究了这种含多巴胺投射系统的功能，并测试了纹状体多巴胺耗竭的影响。单侧多巴胺的损失大大降低了获得的感觉反应的纹状体神经元监测电生理。这种作用是同侧的和选择性的，并可被阿扑吗啡逆转。这些结果表明，灵长类动物黑质纹状体系统调节纹状体神经元反应可塑性的表达在感觉运动学习。
Dysfunction of the nigrostriatal dopamine system results in marked disorders of movement such as occur in Parkinson's disease. Functions of this dopamine-containing projection system were examined in monkeys trained in a classical conditioning task, and the effects of striatal dopamine depletion were tested. Unilateral dopamine loss substantially reduced the acquired sensory responsiveness of striatal neurons monitored electrophysiologically. This effect was ipsilateral and selective, and could be reversed by apomorphine. These results suggest that the primate nigrostriatal system modulates expression of neuronal response plasticity in the striatum during sensorimotor learning.