Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients.
Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients.
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DOI：
10.1186/1471-244x-5-6
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发表时间：
2005-01-31
期刊：
影响因子：
4.4
通讯作者：
Iyo M
中科院分区：
文献类型：
--
作者：
Hashimoto K;Engberg G;Shimizu E;Nordin C;Lindström LH;Iyo M
最近的磁共振波谱(MRS)研究报告说，精神分裂症患者的大脑中的谷氨酰胺发生了变化。精神分裂症患者脑脊液(CSF)中的谷氨酸也有相互矛盾的发现，而谷氨酰胺则缺失。本研究旨在阐明首发和药物未成熟的精神分裂症患者脑脊液中谷氨酰胺和谷氨酸的问题。用高效液相色谱法测定了25例首发及药物未用药男性精神分裂症患者和17例健康男性脑脊液中谷氨酰胺和谷氨酸的含量。比率(126.1(中位数)，117.7±27.4(平均数±S.D.))脑脊液中谷氨酰胺/谷氨酸比值(z=-3.2 9，p=0.001)显著高于(中位数)(89.1±2.5)(中位数)。虽然患者的谷氨酰胺和谷氨酸水平与正常对照组无明显差异，但与正常对照组相比差异有统计学意义。我们的数据表明，大脑中谷氨酸-谷氨酰胺循环的功能障碍可能在精神分裂症的病理生理学中起作用。
Recent magnetic resonance spectroscopy (MRS) studies report that glutamine is altered in the brains of schizophrenic patients. There were also conflicting findings on glutamate in cerebrospinal fluid (CSF) of schizophrenic patients, and absent for glutamine. This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients. Levels of glutamine and glutamate in CSF of 25 first episode and drug-naive male schizophrenic patients and 17 age-matched male healthy controls were measured by a high performance liquid chromatography. The ratio (126.1 (median), 117.7 ± 27.4 (mean ± S.D.)) of glutamine to glutamate in the CSF of patients was significantly (z = -3.29, p = 0.001) higher than that (81.01 (median), 89.1 ± 22.5 (mean ± S.D.)) of normal controls although each level of glutamine and glutamate in patients was not different from that of normal controls. Our data suggests that a disfunction in glutamate-glutamine cycle in the brain may play a role in the pathophysiology of schizophrenia.