Apomorphine selectively stimulates opiocortin hormone release from the pars distalis in rats.
Apomorphine selectively stimulates opiocortin hormone release from the pars distalis in rats.
复制标题
阿朴吗啡选择性刺激大鼠远端部释放阿皮皮质素激素。
DOI：
10.1016/0014-2999(85)90267-5
复制
发表时间：
1985
影响因子：
5
通讯作者：
Mueller,GP
中科院分区：
文献类型：
--
作者：
FarahJr,JM;Sapun-Malcolm,D;Mueller,GP
阿波啡（0.3 ~ 3.0 mg/kg s.c）可引起大鼠循环免疫反应性β-内啡肽（i - β-end）水平快速升高（10 min）。通过凝胶过滤层析判断，几乎所有增加的i - β- end在分子大小上都与β-促脂素（β-LPH）相似。多巴胺拮抗剂氟哌啶醇（0.1 mg/kg i.p, 2 h）或糖皮质激素地塞米松（50 μg/kg i.p, 4 h）预处理均可抑制阿波吗啡反应。综上所述，这些结果表明多巴胺受体的激活刺激远侧部促肾上腺皮质激素的释放。
Administration of apomorphine (0.3–3.0 mg/kg s.c.) evoked a rapid increase (10 min) in circulating levels of immunoreactive β-endorphin (iβ-END) in rats. As judged by gel filtration chromatography, virtually all of the increase corresponded to iβ-END resembling β-lipotropin (β-LPH) in molecular size. The apomorphine response was inhibited by pretreatment with either the dopamine antagonist, haloperidol (0.1 mg/kg i.p., 2 h) or the glucocorticoid, dexamethasone (50 μg/kg i.p., 4 h). Together, these results indicate that dopamine-receptor activation stimulates the release of opiocortin hormones from corticotrophs of the pars distalis.