Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career.
Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career.
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DOI：
10.1007/s00401-023-02644-3
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发表时间：
2023-12
影响因子：
12.7
通讯作者：
中科院分区：
文献类型：
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作者：
人们担心与接触性运动参与相关的晚期不良脑健康结果，在前美式足球[3，8]，足球[9，16]和橄榄球联盟运动员[15]的研究中报告了高神经退行性疾病风险。同时，对来自一系列接触性运动的前运动员的尸检研究描述了慢性创伤性脑病（CTE）的频繁发现，这是一种与创伤性脑损伤（TBI）和重复头部撞击（RHI）暴露既往史唯一相关的神经病理学[7，12-14]。在接触性运动中，橄榄球联盟（以下简称“橄榄球”）被记录为具有脑震荡/轻度TBI的高风险，报告的受伤率范围为社区水平的4.1脑震荡/1000运动员小时[2]至职业橄榄球的22.2脑震荡/1000运动员小时[4]。然而，尽管CTE很受欢迎，据报道全球有846万活跃参与者[20]，但前橄榄球运动员中CTE的病例描述相对较少[7，17，18]。为了解决这个问题，我们整理和分析了神经病理学数据，从尸检脑检查的个人与橄榄球作为主要运动暴露提交给三个国际脑库接触运动和大脑健康的具体利益。对了解神经损伤和创伤性脑病脑库（UNITE;美国波士顿大学医学院）、格拉斯哥TBI档案（GTBI;英国格拉斯哥大学）和澳大利亚运动脑库（ASBB;澳大利亚悉尼大学皇家阿尔弗雷德王子医院）的病例记录进行了调查，以确定主要运动暴露记录为“橄榄球联盟”的病例捐赠。每个档案采用标准化程序进行病例累积、临床病史采集和组织处理，神经病理学评价对人口统计学和临床信息不知情，并采用既定共识方案评估神经退行性疾病病理学，包括CTE [1，11，13]。为了这项研究的目的，现有的
There is concern over late, adverse brain health outcomes associated with contact sports participation, with high neurodegenerative disease risk reported in studies of former American football [3, 8], soccer [9, 16] and rugby union players [15]. In parallel, autopsy studies of former athletes from a range of contact sports describe a frequent finding of chronic traumatic encephalopathy (CTE), a neuropathology uniquely associated with prior history of traumatic brain injury (TBI) and repetitive head impact (RHI) exposure [7, 12–14]. Among contact sports, rugby union (hereafter ‘rugby’) is documented as having high risk of concussion/mild TBI, with reported injury rates ranging 4.1 concussions/1000 player hours at community level [2] to 22.2 concussions/1000 player hours in professional rugby [4]. Nevertheless, despite its popularity, with a reported 8.46 million active participants globally [20], there have been relatively few case descriptions of CTE in former rugby players [7, 17, 18]. To address this, we collated and analyzed neuropathological data from autopsy brain examinations on individuals with rugby as primary sport exposure submitted to three international brain banks with specific interest in contact sport and brain health. Case records of the Understanding Neurologic Injury and Traumatic Encephalopathy Brain Bank (UNITE; Boston University School of Medicine, US), the Glasgow TBI Archive (GTBI; University of Glasgow, UK) and the Australian Sports Brain Bank (ASBB; Royal Prince Alfred Hospital and University of Sydney, Australia) were surveyed to identify case donations in which primary sport exposure was recorded as ‘rugby union’. Each archive employs standardized procedures for case accrual, clinical history acquisition and tissue processing, with neuropathological evaluations conducted blind to demographic and clinical information and employing established, consensus protocols for assessment of neurodegenerative disease pathologies, including CTE [1, 11, 13]. For the purposes of this study, existing
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影响因子：
3.2
作者：
Bieniek KF;Cairns NJ;Crary JF;Dickson DW;Folkerth RD;Keene CD;Litvan I;Perl DP;Stein TD;Vonsattel JP;Stewart W;Dams-O'Connor K;Gordon WA;Tripodis Y;Alvarez VE;Mez J;Alosco ML;McKee AC;TBI/CTE Research Group
通讯作者：
TBI/CTE Research Group
影响因子：
29
作者：
Russell ER;Mackay DF;Stewart K;MacLean JA;Pell JP;Stewart W
通讯作者：
Stewart W
影响因子：
12.7
作者：
通讯作者：
--
影响因子：
29
作者：
Mckee, Ann C.;Mez, Jesse;Abdolmohammadi, Bobak;Butler, Morgane;Huber, Bertrand Russell;Uretsky, Madeline;Babcock, Katharine;Cherry, Jonathan D.;Alvarez, Victor E.;Martin, Brett;Tripodis, Yorghos;Palmisano, Joseph N.;Cormier, Kerry A.;Kubilus, Caroline A.;Nicks, Raymond;Kirsch, Daniel;Mahar, Ian;Mchale, Lisa;Nowinski, Christopher;Cantu, Robert C.;Stern, Robert A.;Daneshvar, Daniel;Goldstein, Lee E.;Katz, Douglas I.;Kowall, Neil W.;Dwyer, Brigid;Stein, Thor D.;Alosco, Michael L.
通讯作者：
Alosco, Michael L.
影响因子：
14.5
作者：
McKee, Ann C.;Stein, Thor D.;Cantu, Robert C.
通讯作者：
Cantu, Robert C.