AGE AND BONE MASS AS PREDICTORS OF FRACTURE IN A PROSPECTIVE-STUDY
AGE AND BONE MASS AS PREDICTORS OF FRACTURE IN A PROSPECTIVE-STUDY
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DOI：
10.1172/jci113523
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发表时间：
1988-06-01
影响因子：
15.9
通讯作者：
JOHNSTON, CC
中科院分区：
文献类型：
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作者：
HUI, SL;SLEMENDA, CW;JOHNSTON, CC
为了研究骨量对骨折风险的影响，我们对521名高加索女性进行了平均6.5年的随访，并在桡骨处反复测量骨量。我们在3388人中每年观察到138例非脊柱骨折。随访的人年数和骨折事件按年龄和骨量交叉分类。然后将骨折发生率拟合到年龄和骨量的长线性模型中。骨折发生率随年龄的增加和桡骨骨量的减少而增加。当对骨折亚群进行检查时，发现年龄是髋部骨折的一个更强的预测因子，而中轴桡骨质量是前臂远端骨折的一个更强的预测因子。我们的结论是，骨量是骨折的一个有用的预测指标，但与骨折相关的其他年龄相关因素需要确定。
To study the effect of bone mass on the risk of fracture, we followed 521 Caucasian women over an average of 6.5 yr and took repeated bone mass measurements at the radius. We observed 138 nonspinal fractures in 3,388 person-yr. The person-years of follow-up and the incident fractures were cross-classified by age and bone mass. The incidence of fracture was then fitted to a long-linear model in age and bone mass. It was found that incidence of fracture increased with both increasing age and decreasing radius bone mass. When subsets of fractures were examined it was found that age was a stronger predictor of hip fractures, whereas midshaft radius bone mass was a stronger predictor of fractures at the distal forearm. We concluded that bone mass is a useful predictor of fractures but that other age-related factors associated with fractures need to be identified.