Divergent effects of a dnaK mutation on abnormal protein degradation in Escherichia coli
Divergent effects of a dnaK mutation on abnormal protein degradation in Escherichia coli
复制标题
dnaK 突变对大肠杆菌异常蛋白质降解的不同影响
DOI：
10.1111/j.1365-2958.1988.tb00004.x
复制
发表时间：
1988
影响因子：
3.6
通讯作者：
Simon Ld
中科院分区：
文献类型：
--
作者：
Keller Ja;Simon Ld
总结
大肠杆菌细菌产生至少一种70 kD的应激蛋白，即dnaK基因的产物。我们比较了不同类型的异常蛋白质在空离子E中的降解速率。大肠杆菌与部分缺失的dnaK基因的速率在null离子dnaK+细胞中观察到。我们已经发现刀豆蛋白和嘌呤霉素多肽在无效dnaK突变体中比在dnaK+菌株中降解得更慢。然而，温度敏感的突变体Lacl蛋白在无效dnaK菌株中降解得更快。还在各种其他条件下详细检查了这种温度敏感性Lad蛋白的稳定性。
Summary
Escherichia coli bacteria produce at least one 70 kD stress protein, the product of the dnaK gene. We have compared the rates of degradation of different types of abnormal proteins in null Ion E. coli with a partial deletion of the dnaK gene with the rates observed in null Ion dnaK+ cells. We have found that both canavanyl proteins and puromycyl polypeptides are degraded more slowly in the null dnaK mutants than in the dnaK+ strain. However, a temperature-sensitive mutant Lacl protein is degraded more rapidly in the null dnaK strain. The stability of this temperature-sensitive Lad protein was also examined in detail under various other conditions.
影响因子：
2.9
作者：
BLAKE, MS;JOHNSTON, KH;GOTSCHLICH, EC
通讯作者：
GOTSCHLICH, EC
DOI：
10.1073/pnas.78.8.4728
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CHARETTE, MF;HENDERSON, GW;MARKOVITZ, A
通讯作者：
MARKOVITZ, A