Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene
Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene
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DOI：
10.1006/bbrc.2001.4588
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发表时间：
2001-03-30
影响因子：
3.1
通讯作者：
Kobayashi, M
中科院分区：
文献类型：
--
作者：
Aoki, S;Higuchi, K;Kobayashi, M
从海绵中分离出的Scalarane型二萜类化合物PHC-1-PHC-7在浓度为0.15 μ g/ml时增加人慢性髓性白血病细胞系K562中血红蛋白的产生。主要成分PHC-1可诱导K562细胞血型糖蛋白A的表达和去核。发现这些二倍半萜类化合物诱导K562细胞中的红系分化。此外，PHC-1还可诱导K562细胞周期发生G1期阻滞。(C)北京：科学出版社.
Scalarane-type sesterterpenes, PHC-1-PHC-7, which have been isolated from a marine sponge, increased hemoglobin production in human chronic myelogenous leukemia cell line K562 at the concentration of 0.15 mug/ml. PHC-1, the major constituent, induced the expression of glycophorin A and the enucleation for K562 cells. These sesterterpenes were found to induce erythroid differentiation in K562 cells. In addition, PHC-1 induced G1 arrest of the cell cycle of K562 cells. (C) 2001 Academic Press.