CEREBROVASCULAR EFFECTS OF AMMONIA INVITRO
CEREBROVASCULAR EFFECTS OF AMMONIA INVITRO
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DOI：
10.1111/j.1748-1716.1981.tb06906.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
LJUNGGREN, B
中科院分区：
文献类型：
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作者：
ANDERSSON, KE;BRANDT, L;LJUNGGREN, B
体外研究了氨（铵盐）对人和兔脑动脉的影响。氨 (NH3/NH4+) 引起脑血管平滑肌松弛，这种松弛是短暂的，并且与血管如何预收缩无关（K-Krebs 溶液、去甲肾上腺素 [去甲肾上腺素]、血清素和前列腺素 F2.α）。该效应与氨诱导的细胞外 pH 值变化无关。氨可能有助于在某些病理生理条件下发生的血管舒张和脑血流量增加。
The effect of ammonia (ammonium salts) upon human and rabbit cerebral arteries was studied in vitro. Ammonia (NH3/NH4+) caused relaxation of cerebrovascular smooth muscle which was transient and occurred irrespective of how the vessels were preconstricted (K-Krebs solution, noradrenaline [norepinephrine], serotinin and prostaglandin F2.alpha.). The effect was independent of ammonia-induced extracelluar changes in pH. Ammonia may contribute to the vasodilation and increase in cerebral blood flow which occurs under certain pathophysiological conditions.