Estimated number of prevalent cases of metastatic bone disease in the US adult population.
Estimated number of prevalent cases of metastatic bone disease in the US adult population.
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DOI：
10.2147/clep.s28339
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发表时间：
2012
影响因子：
3.9
通讯作者：
Arneson TJ
中科院分区：
文献类型：
--
作者：
Li S;Peng Y;Weinhandl ED;Blaes AH;Cetin K;Chia VM;Stryker S;Pinzone JJ;Acquavella JF;Arneson TJ
美国人口中转移性骨病的患病率尚不清楚。我们试图使用两个大型管理数据集来估计当前患有转移性骨病的美国成年人的数量。患病率是根据 2008 年 12 月 31 日覆盖的商业保险队列（年龄 18-64 岁，MarketScan 数据库）和按服务收费的 Medicare 队列（年龄≥65 岁，Medicare 5% 数据库）估计的，每个年龄组约占美国人口的三分之二。我们结合相关诊断和治疗代码，检索了自 2004 年 1 月 1 日以来转移性骨病的索赔证据。美国成年人口中的病例数是根据这些队列中估计的年龄和性别特定患病率推断出来的。列出了所有癌症的合并结果以及原发性乳腺癌、前列腺癌和肺癌的单独结果。在商业保险队列中（平均年龄 = 42.3 岁 [SD = 13.1]），我们确定了 9505 名患有转移性骨病的患者 (0.052%)。乳腺癌是最常见的原发肿瘤类型 (n = 4041)。在 Medicare 队列中（平均年龄 = 75.6 岁 [SD = 7.8]），我们确定了 6427 名 (0.495%) 患有转移性骨病的患者。乳腺癌 (n = 1798) 和前列腺癌 (n = 1862) 是最常见的原发肿瘤类型。我们估计，截至 2008 年 12 月 31 日，有 279,679 名（95% 置信区间：274,579–284,780）美国成年人在过去 5 年内患有转移性骨病。其中 68% 为乳腺癌、前列腺癌和肺癌。我们的研究结果表明，截至 2008 年 12 月 31 日，大约有 280,000 名美国成年人患有转移性骨病。这可能低估了真实频率；并非所有转移性骨病病例均得到诊断，某些诊断病例可能缺乏索赔数据中的记录。
The prevalence of metastatic bone disease in the US population is not well understood. We sought to estimate the current number of US adults with metastatic bone disease using two large administrative data sets. Prevalence was estimated from a commercially insured cohort (ages 18–64 years, MarketScan database) and from a fee-for-service Medicare cohort (ages ≥65 years, Medicare 5% database) with coverage on December 31, 2008, representing approximately two-thirds of the US population in each age group. We searched for claims-based evidence of metastatic bone disease from January 1, 2004, using a combination of relevant diagnosis and treatment codes. The number of cases in the US adult population was extrapolated from age- and sex-specific prevalence estimated in these cohorts. Results are presented for all cancers combined and separately for primary breast, prostate, and lung cancer. In the commercially insured cohort (mean age = 42.3 years [SD = 13.1]), we identified 9505 patients (0.052%) with metastatic bone disease. Breast cancer was the most common primary tumor type (n = 4041). In the Medicare cohort (mean age = 75.6 years [SD = 7.8]), we identified 6427 (0.495%) patients with metastatic bone disease. Breast (n = 1798) and prostate (n = 1862) cancers were the most common primary tumor types. We estimate that 279,679 (95% confidence interval: 274,579–284,780) US adults alive on December 31, 2008, had evidence of metastatic bone disease in the previous 5 years. Breast, prostate, and lung cancers accounted for 68% of these cases. Our findings suggest that approximately 280,000 US adults were living with metastatic bone disease on December 31, 2008. This likely underestimates the true frequency; not all cases of metastatic bone disease are diagnosed, and some diagnosed cases might lack documentation in claims data.