Fat distribution and cardiovascular risk factors in obese adolescent girls: Importance of the intraabdominal fat depot
Fat distribution and cardiovascular risk factors in obese adolescent girls: Importance of the intraabdominal fat depot
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DOI：
10.1093/ajcn/64.1.12
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发表时间：
1996-07-01
影响因子：
7.1
通讯作者：
Tamborlane, WV
中科院分区：
文献类型：
--
作者：
Caprio, S;Hyman, LD;Tamborlane, WV
身体脂肪的区域分布已多次被发现是肥胖男性和女性心血管疾病的重要且独立的危险因素。为了确定脂质脂蛋白谱以及收缩压和舒张压的异常是否与肥胖早期的特定脂肪库有关，我们使用磁共振成像准确测量了 14 名肥胖 [体重指数 (BMI；单位为 kg/m(2)) 30 +/- 1.3] 和 10 名非肥胖 (BMI：21 +/- 0.5) 青春期女孩的腹内和皮下脂肪量，这些女孩的年龄和 Tanner 阶段相匹配。发展。肥胖女孩的腹内和皮下脂肪库比非肥胖女孩多两到三倍（P < 0.01）。肥胖少女的总胆固醇、三酰甘油、低密度脂蛋白（LDL）胆固醇、基础胰岛素、收缩压和舒张压均显着高于对照组。在肥胖女孩中，腹内脂肪而非BMI或腰臀比与基础胰岛素（r = 0.55，P < 0.04）、三酰甘油（r = 0.53，P < 0.03）和高密度脂蛋白（HDL）胆固醇（r = -0.54，P < 0.04）高度相关。肥胖女孩的股骨脂肪组织与三酰甘油（r = -0.51）和低密度脂蛋白胆固醇（r = -0.56，P < 0.05）浓度呈负相关。研究表明，在肥胖青春期女孩的自然史早期，心血管危险因素与腹内脂肪量有关。
The regional distribution of body fat has repeatedly been found to be a significant and independent risk factor for cardiovascular disease in both obese men and women. To determine whether abnormalities in the lipid-lipoprotein profile and systolic and diastolic blood pressure are related to specific fat depots early in the course of obesity, we used magnetic resonance imaging to measure accurately intraabdominal and subcutaneous fat masses in 14 obese [body mass index (BMI; in kg/m(2)) 30 +/- 1.3] and 10 nonobese (BMI: 21 +/- 0.5) adolescent girls matched for age and Tanner stage of development. Intraabdominal and subcutaneous fat depots were two- to threefold greater in obese than in nonobese girls (P < 0.01). Total cholesterol, triacylglycerol, low-density-lipoprotein (LDL) cholesterol, basal insulin, and systolic and diastolic blood pressure were significantly higher in obese adolescent girls than in control subjects. In obese girls, intraabdominal fat but not BMI or waist-to-hip ratio was highly correlated with basal insulin (r = 0.55, P < 0.04), triacylglycerols (r = 0.53, P < 0.03), and high-density-lipoprotein (HDL) cholesterol (r = -0.54, P < 0.04). Femoral adipose tissue was inversely related to triacylglycerol (r = -0.51) and LDL cholesterol (r = -0.56, P < 0.05) concentrations in obese girls. The study indicates that early in the natural history of obese adolescent girls, cardiovascular risk factors are related to the amount of intraabdominal fat.