Immunological perspectives on the pathogenesis, diagnosis, prevention and treatment of COVID-19.
Immunological perspectives on the pathogenesis, diagnosis, prevention and treatment of COVID-19.
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DOI：
10.1186/s43556-020-00015-y
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发表时间：
2021
影响因子：
4
通讯作者：
Wei X
中科院分区：
文献类型：
--
作者：
Ni Y;Alu A;Lei H;Wang Y;Wu M;Wei X
冠状病毒病2019 （COVID-19）是一种由严重急性呼吸综合征冠状病毒2 （SARS-COV-2）引起的急性呼吸道疾病。COVID-19可以扩散到全身并导致多器官衰竭。由于目前没有有效的预防和治疗战略，控制这一快速增长的全球大流行病是一项艰巨的挑战。一般来说，病毒感染引发的人体免疫反应对病毒的消除至关重要。但重症患者可能出现免疫反应失调，如淋巴细胞减少、淋巴细胞耗竭、抗体反应加剧、细胞因子释放综合征（CRS）等。了解这些免疫学特征可能有助于确定更好的诊断、预后和治疗COVID-19患者的方法。由于开发特异性抗病毒药物非常困难，因此通过开发新疫苗或使用免疫疗法来调节免疫反应的策略对于改善SARS-CoV-2感染的管理具有很大的希望。
Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). COVID-19 can spread to the entire body and cause multiple organ failure. It is a daunting challenge to control the fast growing worldwide pandemic because effective prevention and treatment strategies are unavailable currently. Generally, the immune response of the human body triggered by viral infection is essential for the elimination of the virus. However, severe COVID-19 patients may manifest dysregulated immune responses, such as lymphopenia, lymphocyte exhaustion, exacerbated antibody response, cytokine release syndrome (CRS), etc. Understanding of these immunological characteristics may help identify better approaches for diagnosis, prognosis and treatment of COVID-19 patients. As specific anti-viral agents are notoriously difficult to develop, strategies for modulating the immune responses by either developing novel vaccines or using immunotherapy hold great promise to improve the management of SARS-CoV-2 infection.