Per- and polyfluoroalkyl substances in the atmospheric total suspended particles in Karachi, Pakistan: Profiles, potential sources, and daily intake estimates
Per- and polyfluoroalkyl substances in the atmospheric total suspended particles in Karachi, Pakistan: Profiles, potential sources, and daily intake estimates
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巴基斯坦卡拉奇大气总悬浮颗粒中的全氟烷基物质和多氟烷基物质：概况、潜在来源和每日摄入量估计
DOI：
10.1016/j.chemosphere.2021.132432
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发表时间：
2022
期刊：
影响因子：
8.8
通讯作者：
Khwaja Haider Abbas
中科院分区：
文献类型：
--
作者：
Lin Huiju;Taniyasu Sachi;Yamashita Nobuyoshi;Khan Muhammad Kamran;Masood Saiyada Shadiah;Saied Sumayya;Khwaja Haider Abbas
全氟烷基物质和多氟烷基物质(全氟烷基物质)一直受到关注；然而，对其在大气中的来源和相关的人类暴露风险的了解有限。这项研究测量了冬季从巴基斯坦卡拉奇采集的大气总悬浮颗粒物中的全氟辛烷磺酸。在定量的全氟丁酸(PFBA)中，全氟丁酸(PFBA)的平均浓度最高(3.11±2.64)pg/m~3，占PFAS总量的32%。风速与全氟己酸(PFHxA)和N-乙基全氟辛烷磺酸(N-EtFOSA)呈正相关，相对湿度与全氟辛酸(PFOS)和全氟辛酸(PFOA)呈负相关。加权势源贡献函数(WPSCF)和浓度加权轨迹(WCWT)分析表明，巴基斯坦西北部和阿富汗西部地区与PFAS的远程大气输送高度相关。我们还计算了吸入全氟辛烷磺酸的日摄入量，儿童和成人的日摄入量分别为0.07-3.98和0.01-0.33微克/公斤体重/天。全氟辛烷磺酸和全氟辛烷磺酸的计算危害商(HQ)显著低于1，表明吸入暴露不会或不太可能造成非致癌影响。总体而言，这项研究有助于在区域范围内了解空气中全氟辛烷磺酸的地理来源和人类吸入风险。
Per- and polyfluoroalkyl substances (PFAS) have received continuous attention; however, there is limited understanding of their sources in the atmosphere and related human exposure risks. This study measured PFAS in the atmospheric total suspended particles collected from Karachi, Pakistan, during the winter. Among the quantified PFAS, perfluorobutanoic acid (PFBA) showed the highest average concentration (3.11 ± 2.64 pg/m3), accounting for 32% of the total PFAS. Wind speed was positively correlated with perfluorohexanoic acid (PFHxA) andN-ethyl perfluorooctanesulfonamide (N-EtFOSA), while relative humidity was negatively correlated with perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Weighted potential source contribution function (WPSCF) and concentration weighted trajectory (WCWT) analyses suggested that northwestern Pakistan and western Afghanistan areas were highly associated with the long-range atmospheric transport of PFAS. We also calculated the daily intake of PFAS via inhalation, which were in the range of 0.07–3.98 and 0.01–0.33 pg/kg bw/d for children and adults, respectively. The calculated hazard quotient (HQ) of PFOS and PFOA was significantly lower than 1, indicating less or unlikely to cause non-carcinogenic effect via inhalation exposure. Overall, this study contributes to the understanding of geographic origins and human inhalation risks of airborne PFAS on a regional scale.