ASSOCIATION OF ANTINEOPLASTIC DRUG HANDLING WITH ACUTE ADVERSE-EFFECTS IN PHARMACY PERSONNEL
ASSOCIATION OF ANTINEOPLASTIC DRUG HANDLING WITH ACUTE ADVERSE-EFFECTS IN PHARMACY PERSONNEL
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DOI：
10.1093/ajhp/50.3.455
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发表时间：
1993-03-01
期刊：
影响因子：
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通讯作者：
GLASS, AG
中科院分区：
文献类型：
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作者：
VALANIS, BG;VOLLMER, WM;GLASS, AG
采用问卷调查的方法调查职业接触抗肿瘤药物与急性接触症状的关系。数据来自全国57个国家乳腺和肠外科辅助项目成员机构的8566名药剂师、药学技术人员、护士和护工的问卷调查。受访4659人（54%）中，药师或药学技术人员1057人；排除后，样本量为738。收集了四项处理活动的数据：混合抗肿瘤药物、给药、清理溢出物和处理患者排泄物。有关混合的信息分为剂量、持续时间、使用保护和报告的皮肤接触。答复者指出了他们在过去三个月中经历过的27种急性症状中的哪一种。与对照组相比，抗肿瘤药物的处理与症状数量虽小但显著增加有关；报告的皮肤接触是症状最重要的预测因子。处理剂量的数量和保护程度与症状的数量显著相关，但它们的影响并非与皮肤接触无关。女性的体重与症状数量显著相关，而男性没有。使用抗肿瘤药物的药剂师和技术人员报告的与接触这些药物相关的症状比不使用这些药物的人更多。应采取一切可用的保护措施。
The relationship between occupational exposure to antineoplastic drugs and the presence of acute symptoms of exposure was investigated by questionnaire.Data were derived from a questionnaire distributed to 8566 pharmacists, pharmacy technicians, nurses, and nurse aides at 57 member institutions of the National Surgical Adjuvant Breast and Bowel Project nationwide. 0 the 4659 respondents (54%), 1057 were pharmacists or pharmacy technicians; after exclusions, the sample size was 738. Data were collected on four handling activities: mixing of antineoplastic drugs, administering these drugs, cleaning up spills, and handling patient excreta. Information on mixing was divided into dose, duration, use of protection, and reported skin contact. Respondents indicated which of 27 acute symptoms they had experienced during the past three months.Handling of antineoplastics was associated with a small but significant increase in the number of symptoms compared with controls; reported skin contact was the most important predictor of symptoms. The number of doses handled and the extent of protection were significantly associated with the number of symptoms, but their effect was not independent of that of skin contact. Body mass was significantly associated with the number of symptoms in women but not men.Pharmacists and technicians who handle antineoplastic drugs reported more symptoms associated with exposure than did those who do not handle such agents. All available protective measures should be used.