Effects of chronic prednisone therapy on mood and memory
Effects of chronic prednisone therapy on mood and memory
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DOI：
10.1016/j.jad.2006.09.004
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发表时间：
2007-04-01
影响因子：
6.6
通讯作者：
Johnson, Brandy
中科院分区：
文献类型：
--
作者：
Brown, E. Sherwood;Vera, Elizabeth;Johnson, Brandy
背景：在动物中，应激和皮质类固醇可与海马的可逆和不可逆变化相关。一些情绪障碍患者的记忆和海马结构发生变化，可能部分是由于皮质醇升高。关于长期暴露于皮质类固醇对人类海马体的影响的数据很少。我们以前报道了更大的抑郁症状的严重程度，记忆力较差，海马体积较小的哮喘或风湿性疾病患者接受长期泼尼松治疗比controls.Methods：在这份报告中，患者和对照组进行了评估，平均4年后，第一次评估，以确定是否抑郁和躁狂症状和认知保持稳定，改善或恶化。七个强的松治疗的患者和六个对照组被确定，并同意重新评估精神症状和神经认知措施。随访MRI海马体积分析可用于两个泼尼松治疗的participant.Results：除了在那些接受泼尼松的抑郁症状的增加，参与者和对照组并没有表现出显着的变化，情绪或认知从最初的评估。一名参与者停用泼尼松，精神症状和认知能力有所改善。海马体积在两个泼尼松治疗的参与者，并表现出不一致的findings.Limitations：一个限制是小样本size.Conclusions：我们的研究结果，虽然初步性质，表明，长期泼尼松治疗与情绪，记忆和海马体积的初步变化，似乎随着时间的推移稳定。(c)2006 Elsevier B.V.保留所有权利。
Background: In animals, stress and corticosteroids can be associated with both reversible and irreversible changes in the hippocampus. Changes in memory and hippocampal structure, perhaps in part due to cortisol elevations, are reported in some patients with mood disorders. Minimal data are available on the effects of long-term exposure to corticosteroids on the human hippocampus. We previously reported greater depressive symptom severity, poorer memory and smaller hippocampal volumes in patients with asthma or rheumatic diseases receiving long-term prednisone therapy than in controls.Methods: In this report, patients and controls were assessed a mean of 4 years after the first assessment to determine if depressive and manic symptoms and cognition remained stable, improved or worsened. Seven prednisone-treated patients and six controls were identified and agreed to reassessment with psychiatric symptom and neurocognitive measures. Follow-up MRIs for hippocampal volume analysis were available for two prednisone-treated participants.Results: With the exception of an increase in depressive symptoms in those receiving prednisone, participants and controls did not show significant change in mood or cognition from the initial assessment. One participant discontinued prednisone and showed improvement in psychiatric symptoms and cognition. Hippocampal volumes were available in two prednisone-treated participants and showed inconsistent findings.Limitations: A limitation is the small sample size.Conclusions: Our findings, although preliminary in nature, suggest that long-term prednisone therapy is associated with initial changes in mood, memory and hippocampal volume that appear to stabilize over time. (c) 2006 Elsevier B.V. All rights reserved.