Increase in incidence of adult T-cell leukemia/lymphoma in non-endemic areas of Japan and the United States
Increase in incidence of adult T-cell leukemia/lymphoma in non-endemic areas of Japan and the United States
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DOI：
10.1111/j.1349-7006.2012.02373.x
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发表时间：
2012-10-01
期刊：
影响因子：
5.7
通讯作者：
Matsuo, Keitaro
中科院分区：
文献类型：
--
作者：
Chihara, Dai;Ito, Hidemi;Matsuo, Keitaro
成人T细胞白血病/淋巴瘤(ATLL)是一种与人类T细胞白血病病毒I型(HTLV-1)感染相关的外周T细胞肿瘤。虽然在HTLV-1流行区ATLL的高发病率是众所周知的，但关于非流行区ATLL发病率的基于人群的证据很少。为了回答这个问题，我们估计了1993年至2006年日本和美国1993年至2008年的ATLL年龄标准化发病率，并使用日本基于人群的癌症登记数据和美国的监测流行病学和最终结果(SEER)数据评估了其趋势。日本的数据来自15个县。在研究期间，九州三个县的2055名患者和本州12个县的1380名患者被诊断为atll。在美国，共有140名患者被诊断为ATLL。结果表明，日本和美国非流行区的年龄标化发病率在此期间显著增加(年变化率[95%CI]；日本-本州：+4.6%[1.1，8.2]；美国：+6.2%[1.5，11.1])，而日本流行区无变化(年变化率[95%CI]；日本-九州：0.0%[-1.6，1.7])。这一结果表明，该病已通过携带者传播到非流行地区，并表明有必要制定标准的预防策略。
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T cell neoplasm that is associated with infection by the human T-cell leukemia virus type I (HTLV-1). Although the high incidence of ATLL in HTLV-1-endemic areas is well known, population-based evidence concerning the incidence of ATLL in non-endemic areas is scarce. To answer this, we estimated the age-standardized incidence of ATLL from 1993 to 2006 for Japan and 1993 to 2008 for the US and assessed its trend using data from a population-based cancer registry in Japan and Surveillance Epidemiology and End Results (SEER) in the US. The Japanese data were collected from 15 prefectures. A total of 2055 patients in the three prefectures in Kyushu and 1380 patients in the 12 prefectures in Honshu were diagnosed with ATLL in the study period. In the US, a total of 140 patients were diagnosed with ATLL. The results showed that the age-standardized incidence in non-endemic areas in Japan and in the US significantly increased during this period (annual percent change [95%CI]; Japan-Honshu: +4.6% [1.1, 8.2]; US: +6.2% [1.5, 11.1]), while in the endemic areas of Japan there was no change (annual percent change [95%CI]; Japan-Kyushu: 0.0% [-1.6, 1.7]). This result indicates that the disease has been spread by carriers to non-endemic areas, and suggests the necessity of establishing a standard preventive strategy.