THE NATURE OF CANCER - MORPHOGENESIS AND PROGRESSIVE (SELF)-DISORGANIZATION IN NEOPLASTIC DEVELOPMENT AND PROGRESSION
THE NATURE OF CANCER - MORPHOGENESIS AND PROGRESSIVE (SELF)-DISORGANIZATION IN NEOPLASTIC DEVELOPMENT AND PROGRESSION
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DOI：
10.3109/02841869509093632
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发表时间：
1995-01-01
期刊：
影响因子：
3.1
通讯作者：
CLARK, WH
中科院分区：
文献类型：
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作者：
CLARK, WH
在肿瘤发生之初的事件和五类肿瘤病变的情况下，讨论了肿瘤和癌症的异常生命形式，病变类型为：1)前体状态；2)中度病变；3)原发癌；4)转移;5)转移性转移。一开始的事件是一组不同的因子和机制，诱导病变的前体状态，而不是癌症，由诱导产生的病变和事件是相似的，无论何种因子，因此，在不同的肿瘤系统中必须有相似的生物学原理和机制，肿瘤病变和癌症的分类被描述，并由此衍生出一个理论，该理论是：任何改变一个细胞或一组细胞及其基质的扰动，使它们不再对组织、器官和机体维护的力量作出适当的反应，都可能诱发肿瘤系统。诱导肿瘤系统的病变的顺序进展是一组细胞与其基质之间相互作用连续的一系列缺陷的结果。产生病变的进行性（自我）解体和对组织和器官维持力的反应的进行性丧失。
The aberrant forms of life, neoplasia and cancer, are discussed under the events at the beginning of neoplasia and under five classes of neoplastic lesions, The lesional classes are: 1) The precursor state; 2) Intermediate lesions; 3) Primary cancer; 4) Metastasis; and 5) Metastasis from metastasis. The events at the beginning are a diverse group of agents and mechanisms that induce the lesions of the precursor state, not cancer, The lesions and events produced by induction are similar regardless of the agent, Thus, there must be similar biological principles and mechanisms operative in different neoplastic systems, The classes of neoplastic lesions and cancer are described and a theory derived therefrom, The theory is: Any perturbation that alters a cell or group of cells and their stroma so that they no longer respond appropriately to the forces of tissue, organ, and organismal maintenance, may induce a neoplastic system, The sequential progression of lesions of the induced neoplastic system is the result of a successive series of flaws in the continuum of reciprocal interactions between a group of cells and their stroma, The flaws, appearing seriatim, produce progressive (self)-disorganization of the lesions and progressive loss of response to the forces of tissue and organ maintenance.