Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen
Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen
复制标题
DOI：
10.1126/science.274.5289.995
复制
发表时间：
1996-11-08
期刊：
影响因子：
56.9
通讯作者：
Fukamizu, A
中科院分区：
文献类型：
--
作者：
Takimoto, E;Ishida, J;Fukamizu, A
妊娠期高血压是妊娠期常见的并发症，其病理生理机制尚不清楚。通过与表达人类肾素-血管紧张素系统的转基因小鼠交配，在动物模型中研究了这一现象。当表达血管紧张素原的转基因雌性与表达肾素的转基因雄性交配时，怀孕的雌性在妊娠晚期表现出一过性的血压升高，这是由于胎盘中的人肾素分泌到母体循环中。小狗出生后，血压恢复到正常水平。组织病理学检查显示肾小球均匀增大，伴有尿蛋白排泄增加、心肌肥大、胎盘坏死和水肿。这些小鼠可能提供对人类妊娠高血压的分子洞察力。
Maternal hypertension is a common complication of pregnancy and its pathophysiology is poorly understood. This phenomenon was studied in an animal model by mating transgenic mice expressing components of the human renin-angiotensin system. When transgenic females expressing angiotensinogen were mated with transgenic males expressing renin, the pregnant females displayed a transient elevation of blood pressure in late pregnancy, due to secretion of placental human renin into the maternal circulation. Blood pressure returned to normal levels after delivery of the pup. Histopathologic examination revealed uniform enlargement of glomeruli associated with an increase in urinary protein excretion, myocardial hypertrophy, and necrosis and edema in the placenta. These mice may provide molecular insights into pregnancy-associated hypertension in humans.