Histologic findings one year after positive crossmatch or ABO blood group incompatible living donor kidney transplantation
Histologic findings one year after positive crossmatch or ABO blood group incompatible living donor kidney transplantation
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DOI：
10.1111/j.1600-6143.2006.01416.x
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发表时间：
2006-08-01
影响因子：
8.8
通讯作者：
Stegall, M. D.
中科院分区：
文献类型：
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作者：
Gloor, J. M.;Cosio, F. G.;Stegall, M. D.
最近的方案允许成功的交叉配型阳性（+XM）和ABO血型不合（ABOI）肾移植，尽管其长期结果尚不清楚。为了开始评估这一问题，我们比较了37例+XM、24例ABOI和198例传统同种异体移植物移植后12个月进行的方案活检。尽管三组中的大多数患者仅有轻微的组织学改变，但+XM组的移植肾小球病（TG）显著增加（22% vs. 13%ABOI vs. 8%常规组，p = 0.015），多变量分析显示与既往体液排斥反应（HR）相关（比值比17.5，p
Recent protocols have allowed successful positive crossmatch (+XM) and ABO incompatible (ABOI) kidney transplantation, although their long-term outcome is not clear. To begin to assess this issue we compared protocol biopsies performed 12 months posttransplant in 37 +XM, 24 ABOI and 198 conventional allografts. Although the majority in all three groups had only minimal histologic changes, transplant glomerulopathy (TG) was significantly increased in +XM (22% vs. 13% ABOI vs. 8% conventional, p = 0.015), and correlated with prior humoral rejection (HR) by multivariate analysis (odds ratio 17.5, p