Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES).

Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES).
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DOI:
10.1111/j.1475-6773.2009.01039.x
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发表时间:
2009-12
影响因子:
3.4
通讯作者:
Cunningham WE
Cunningham WE
中科院分区:
医学3区
文献类型:
--
作者:
Newman PA;Lee SJ;Duan N;Rudy E;Nakazono TK;Boscardin J;Kakinami L;Shoptaw S;Diamant A;Cunningham WE

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To assess HIV vaccine acceptability among high-risk adults in Los Angeles. Sexually transmitted disease clinics, needle/syringe exchange programs, Latino community health/HIV prevention programs. Cross-sectional survey using conjoint analysis. Participants were randomly selected using 3-stage probability sampling. 60-minute structured interviews. Participants rated acceptability of 8 hypothetical vaccines each with 7 dichotomous attributes, and reported post-vaccination risk behavior intentions. Participants (n=1164; 55.7% male, 82.4% ethnic minority, mean age=37.4 years) rated HIV vaccine acceptability from 28.4 to 88.6; mean=54.5 (SD=18.8; 100-point scale). Efficacy had the greatest impact on acceptability, followed by side effects and out-of-pocket cost. 10.0% would decrease condom use after vaccination. Findings support development of social marketing interventions to increase acceptability of “partial efficacy” vaccines, behavioral interventions to mitigate risk compensation and targeted cost subsidies.
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