Augmenting immune responses to varicella zoster virus in older adults: A randomized, controlled trial of Tai Chi
Augmenting immune responses to varicella zoster virus in older adults: A randomized, controlled trial of Tai Chi
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DOI：
10.1111/j.1532-5415.2007.01109.x
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发表时间：
2007-04-01
影响因子：
6.3
通讯作者：
Oxman, Michael N.
中科院分区：
文献类型：
--
作者：
Irwin, Michael R.;Olmstead, Richard;Oxman, Michael N.
目的：评估行为干预太极对老年人对水痘带状疱疹病毒（VZV）的静止和疫苗刺激的细胞介导免疫（CMI）水平以及健康功能的影响。设计：前瞻性、随机、对照试验，分为两组（Tal Chi组和健康教育组），为期25周。干预16周后，受试者接种了VARIVAX，这是一种经批准用于预防水痘的Oka/Merck减毒活疫苗。环境：2001年至2005年间的两个美国城市社区。参与者：共有112名59至86岁的健康老年人。测量：主要终点是VZV-CMI的定量测量。次要结果是医疗结果研究36项简短健康调查（SF-36）的得分。结果：太极拳组VZV-CMI水平高于健康教育组(P
OBJECTIVES: To evaluate the effects of a behavioral intervention, Tai Chi, on resting and vaccine-stimulated levels of cell-mediated immunity (CMI) to varicella zoster virus (VZV) and on health functioning in older adults.DESIGN: A prospective, randomized, controlled trial with allocation to two arms (Tal Chi and health education) for 25 weeks. After 16 weeks of intervention, subjects were vaccinated with VARIVAX, the live attenuated Oka/Merck VZV vaccine licensed to prevent varicella.SETTING: Two urban U.S. communities between 2001 and 2005.PARTICIPANTS: A total of 112 healthy older adults aged 59 to 86.MEASUREMENTS: The primary endpoint was a quantitative measure of VZV-CMI. Secondary outcomes were scores on the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36).RESULTS: The Tai Chi group showed higher levels of VZV-CMI than the health education group (P