Visualization of endolymphatic hydrops and correlation with audio-vestibular functional testing in patients with definite Meniere's disease
Visualization of endolymphatic hydrops and correlation with audio-vestibular functional testing in patients with definite Meniere's disease
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DOI：
10.1016/j.anl.2012.07.009
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发表时间：
2013-04-01
影响因子：
1.7
通讯作者：
Lee, Won Sang
中科院分区：
文献类型：
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作者：
Seo, Young Joon;Kim, Jinna;Lee, Won Sang
目的：已有报道使用磁共振成像 (MRI) 对梅尼埃病患者进行内淋巴积水的可视化。然而，MRI 可视化的内淋巴积水与音频前庭功能测试之间的关系尚未得到充分研究，例如纯音测听 (PTA)、耳蜗电图 (EcoG) 和前庭诱发肌源电位 (VEMP)。 方法：在这里，我们尝试在鼓室内使用 3 Tesla (3 T)-MRI 来可视化梅尼埃病患者的内淋巴积水注射钆二乙烯三胺（Gd-DTPA）并将水肿的存在与听觉测试相关联。对 26 名确诊患有梅尼埃病的患者进行鼓室内 Gd-DTPA 造影剂注射后，进行了 3D 流体衰减反转恢复 (3D-FLAIR) 序列成像。 PTA、EcoG 和 VEMP 测试是双边进行的。患者具有梅尼埃病的典型听觉测试结果。结果：3D-FLAIR MRI 清楚地显示了明确的梅尼埃病组中耳蜗 (81%) 和球囊 (69%) 内淋巴积液，并伴有信号空洞。听觉测试证实，可视化耳蜗积水（基底转）与 PTA 中的高音听阈和异常 EcoG 相关。尽管 VEMP 的缺失与 MRI 上的前庭积水无关，但通过影像学检测发现大量前庭积水。这项研究表明，梅尼埃病患者的内淋巴积水可以通过 3D-FLAIR MRI 可视化。结论：使用这些技术可以轻松可视化耳蜗积水和前庭（囊状）积水。 MRI 上显示的水肿可能是诊断梅尼埃病的可靠方法。与听觉前庭功能测试的适当相关性支持了这一点。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
Objectives: Visulization of endolymphatic hydrops has been reported using magnetic resonance imaging (MRI) in patients with Meniere's disease. However, the relationship between the endolymphatic hydrops visualized by MRI and audio-vestibular functional tests have not been sufficiently investigated, such as pure tone audiometry (PTA), electrocochleography (EcoG), and vestibular evoked myogenic potential (VEMP).Methods: Here we attempted to visualize endolymphatic hydrops in patients with Meniere's disease using 3 Tesla (3 T)-MRI following intratympanic gadolinium-diethylene-triamnie petaaetic acidbis (Gd-DTPA) injection and correlated the presence of hydrops with auditory testing. Following intratympanic Gd-DTPA contrast injections in 26 patients diagnosed as having definite Meniere's disease, 3D-fluid-attenuated inversion recovery (3D-FLAIR) sequence imagings were performed. The PTA, EcoG, and VEMP testing was done bilaterally. Patients had typical results of auditory testing for Meniere's disease.Results: The 3D-FLAIR MRI clearly demonstrated endolymphatic hydrops with signal voids in the cochlea (81%) and saccule (69%) in the definite Meniere's disease group. Auditory tests verified that the visualized cochlear hydrops (basal turn) was correlated with a high tone hearing threshold in PTA and an abnormal EcoG. Though the absence of VEMP did not correlate with vestibular hydrops on MRI, large vestibular hydrops were detected by imaging. This study demonstrates that endolymphatic hydrops could be visualized by 3D-FLAIR MRI in Meniere's disease patients.Conclusion: Cochlea hydrops and vestibular (saccular) hydrops are readily visualized using these techniques. Hydrops, as visualized on MRI, may be a reliable means to diagnosis Meniere's disease; this is supported by appropriate correlations with auditory vestibular functional testing. (C) 2012 Elsevier Ireland Ltd. All rights reserved.