Prostaglandins in the pathogenesis of kidney diseases.
Prostaglandins in the pathogenesis of kidney diseases.
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前列腺素在肾脏疾病发病机制中的作用。
DOI：
10.18632/oncotarget.25005
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发表时间：
2018-05-29
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
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作者：
Li Y;Xia W;Zhao F;Wen Z;Zhang A;Huang S;Jia Z;Zhang Y
前列腺素（Prostaglandins, pg）是花生四烯酸通过环氧化酶（cox）和特异性前列腺素合成酶的顺序催化而产生的重要脂质介质。PGs有5种亚型，分别是PGE2、PGI2、PGD2、PGF2α和血栓素A2 （TXA2）。pg通过结合不同的跨膜G蛋白偶联前列腺素受体家族发挥不同的作用。这些pg的分布及其特定的合酶和受体在肾脏中变化很大。本文综述了近年来pg、cox及其特异性合酶和受体在肾脏功能调节中的研究进展，并对其在各种肾脏疾病的发病机制中的作用进行了综述。
Prostaglandins (PGs) are important lipid mediators produced from arachidonic acid via the sequential catalyzation of cyclooxygenases (COXs) and specific prostaglandin synthases. There are five subtypes of PGs, namely PGE2, PGI2, PGD2, PGF2α, and thromboxane A2 (TXA2). PGs exert distinct roles by combining to a diverse family of membrane-spanning G protein-coupled prostanoid receptors. The distribution of these PGs, their specific synthases and receptors vary a lot in the kidney. This review summarized the recent findings of PGs together with the COXs and their specific synthases and receptors in regulating renal function and highlighted the insights into their roles in the pathogenesis of various kidney diseases.