Ultrasmall Gold Nanoparticles Behavior in Vivo Modulated by Surface Polyethylene Glycol (PEG) Grafting
Ultrasmall Gold Nanoparticles Behavior in Vivo Modulated by Surface Polyethylene Glycol (PEG) Grafting
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DOI：
10.1021/acs.bioconjchem.6b00488
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发表时间：
2017-01-01
影响因子：
4.7
通讯作者：
Liang, Xing-Jie
中科院分区：
文献类型：
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作者：
Huo, Shuaidong;Chen, Shizhu;Liang, Xing-Jie
超小纳米颗粒为我们设计更有效的药物递送纳米载体提供了必要的选择。然而，超小纳米颗粒的快速清除在一定程度上限制了其应用。聚乙二醇是一种最常用的减缓纳米载体和纳米药物清除的化合物，也获得了FDA的批准。然而，很少有报道探讨超小纳米颗粒聚乙二醇化对其体内行为的影响。在此，我们研究了不同PEG接枝水平的2 nm核尺寸金纳米颗粒对其在荷瘤小鼠体内生物学行为的影响。结果表明，部分（接近50%）表面PEGylation可以最大程度地延长血液循环，增加超小纳米颗粒的肿瘤蓄积，这将指导我们构建更有利的小尺寸药物递送纳米载体。
Ultrasmall nanoparticles provide us with essential alternatives for designing more efficient nanocarriers for drug delivery. However, the fast clearance of ultrasmall nanoparticles limits their application to some extent. One of the most frequently used compound to slow the clearance of nanocarriers and nanodrugs is PEG, which is also approved by FDA. Nonetheless, few reports explored the effect of the PEGylation of ultrasmall nanoparticles on their behavior in vivo. Herein, we investigated the impact of different PEG grafting level of 2 nm core sized gold nanoparticles on their biological behavior in tumor-bearing mice. The results indicate that partial (similar to 50%) surface PEGylation could prolong the blood circulation and increase the tumor accumulation of ultrasmall nanoparticles to a maximum extent, which guide us to build more profitable small-sized nanocarriers for drug delivery.