Prevalence and Incidence of Mild Cognitive Impairment across Subtypes, Age, and Sex
Prevalence and Incidence of Mild Cognitive Impairment across Subtypes, Age, and Sex
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DOI：
10.1159/000499763
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发表时间：
2019-10-01
影响因子：
2.4
通讯作者：
Elmstahl, Solve
中科院分区：
文献类型：
--
作者：
Overton, Marieclaire;Pihlsgard, Mats;Elmstahl, Solve
目的：本研究的目的是在以人群为基础的样本中，根据不同的标准，报告不同年龄、性别和亚型的轻度认知损害(MCI)的患病率和发病率。方法：样本来自瑞典斯堪尼亚良好老龄化(G Angstrom S)人群研究，并使用3,752名60岁及以上参与者的数据来计算MCI患病率。发病率是通过2093名参与者和6年的随访数据计算出来的。MCI的定义根据扩展的Mayo Clinic标准：认知主诉、客观认知损害(两个不同的标准取决于损害的严重程度)、保留的功能能力和无痴呆。结果：根据年龄和损伤的严重程度，患病率估计在5.13%到29.9%之间。轻度和重度认知损害的总MCI发生率分别为每千人年22.6(95%可信区间：19.6-25.9)和8.67(95%可信区间：7.0-10.7)。“非遗忘性MCI单一领域”的患病率和发病率估计最高。年龄越大患病率越高，在MCI发病率上没有性别或年龄差异。结论：我们的发现与先前的研究一致，认为MCI是一个不同的概念，因为根据年龄、MCI亚型和认知损害的严重程度，患病率和发病率估计有很大的不同。
Objective: The purpose of this study was to report on the prevalence and incidence of mild cognitive impairment (MCI) across age, sex, and subtypes according to various criteria in a population-based sample. Methods: The sample was drawn from the Swedish Good Aging in Skane (G angstrom S) population study, and data from 3,752 participants aged 60 years and more were used to calculate the MCI prevalence. The incidence was calculated using 2,093 participants with 6-year follow-up data. MCI was defined according to the expanded Mayo Clinic criteria: cognitive complaint, objective cognitive impairment (two different criteria depending on the severity of impairment), preserved functional abilities, and no dementia. Results: The prevalence estimates ranged from 5.13 to 29.9% depending on age and severity of impairment. The incidence rates of overall MCI were 22.6 (95% confidence interval [CI]: 19.6-25.9) and 8.67 (95% CI: 7.0-10.7) per 1,000 person-years for less severe and severe cognitive impairment, respectively. The highest prevalence and incidence estimates were found for "non-amnestic MCI single domain." The older age groups had a higher prevalence, and no sex or age differences in MCI incidence were detected. Conclusion: Our findings concur with previous research advocating that MCI is a heterogeneous concept, since the prevalence and incidence estimates differed substantially according to age, MCI subtype, and severity of cognitive impairment.