Mitophagy: Critical Role in Atherosclerosis Progression
Mitophagy: Critical Role in Atherosclerosis Progression
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线粒体自噬：在动脉粥样硬化进展中的关键作用
DOI：
10.1089/dna.2022.0249
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发表时间：
2022-08-26
影响因子：
3.1
通讯作者：
Wei, Dangheng
中科院分区：
文献类型：
--
作者：
Chen, Yanmei;Qin, Wenhua;Wei, Dangheng
自噬维持心血管系统中的细胞内稳态，包括心肌细胞、内皮细胞（EC）和动脉平滑肌细胞。线粒体自噬是一种选择性自噬，专门清除受损和功能失调的线粒体，对心血管稳态特别重要。线粒体自噬功能障碍导致心血管疾病，特别是动脉粥样硬化（AS）。本文就线粒体自噬的调控机制及其在AS中的作用作一综述。这一发现有助于了解动脉粥样硬化病变的病理过程，为AS的预防和临床治疗提供了新的思路。
Autophagy maintains intracellular homeostasis in the cardiovascular system, including in cardiomyocytes, endothelial cells (ECs), and arterial smooth muscle cells. Mitophagy, a selective autophagy that specifically removes damaged and dysfunctional mitochondria, is particularly important for cardiovascular homeostasis. Dysfunctional mitophagy contributes to cardiovascular disease, particularly atherosclerosis (AS). This review focuses on the advances of regulator mechanisms of mitophagy and its potential roles in AS. The findings are beneficial to understanding the pathological processes of atherosclerotic lesions and provide new ideas for the prevention and clinical treatment of AS.