Vitamin D levels in Jamaican patients with systemic lupus erythematosus
Vitamin D levels in Jamaican patients with systemic lupus erythematosus
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DOI：
10.1177/0961203314528556
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发表时间：
2014-09-01
期刊：
影响因子：
2.6
通讯作者：
Lee, M. G.
中科院分区：
文献类型：
--
作者：
McGhie, T. K.;DeCeulaer, K.;Lee, M. G.
维生素 D 对免疫系统具有重要影响，因为它已被证明具有抗增殖和相对免疫抑制作用。这种激素的低水平可能有助于系统性红斑狼疮 (SLE) 和其他自身免疫性疾病的免疫激活。使用酶联免疫测定法测量了牙买加 75 名 SLE 患者的血清 25-OH 维生素 D 水平。确定了 BILAG 指数确定的与临床数据和疾病活动的相关性。在总共 75 名患者中，33 名 (44%) 维生素 D 充足，平均维生素 D 水平为 39.45 ng/ml（范围为 30.35-58.16）。 42 名 (56%) 患者存在维生素 D 缺乏或不足，其中 30 名 (40%) 患者存在维生素 D 不足，平均水平为 26.36 ng/ml（范围为 20.26-29.88），12 名患者（16%）存在维生素 D 缺乏，平均水平为 16.07 ng/ml（范围为 7.78-19.90）。使用 BILAG 指数得出的总疾病活动评分与维生素 D 水平之间存在总体负相关关系，这主要受到维生素 D 缺乏亚组中观察到的关系的影响。这也受到疾病活动度明显偏低的患者群体的影响。负关联趋于统计显着性。牙买加 SLE 患者普遍缺乏维生素 D。低血清维生素 D 水平与 SLE 活动之间可能存在关联。
Vitamin D has important effects on the immune system as it has been shown to exert antiproliferative and relative immunosuppressant effects. Low levels of this hormone may contribute to the immune activation in systemic lupus erythematosus (SLE) and other autoimmune diseases. Serum levels of 25-OH vitamin D were measured in 75 patients with SLE in Jamaica, using an enzyme-linked immunoassay. Correlations with clinical data and disease activity as determined by the BILAG index were determined. Of a total of 75 patients, 33 (44%) had vitamin D sufficiency with mean vitamin D level of 39.45 ng/ml (range, 30.35-58.16). Forty-two (56%) patients had either vitamin D deficiency or insufficiency, 30 (40%) had vitamin D insufficiency, mean 26.36 ng/ml (range, 20.26-29.88), and 12 (16%) had vitamin D deficiency, mean 16.07 ng/ml (range, 7.78-19.90). There was an overall negative relationship between the total disease activity score using the BILAG index and vitamin D levels, and this was influenced primarily by the relationship seen among the vitamin D-deficient subgroup. This was also impacted on by a patient population that was significantly skewed toward low disease activity. The negative association trended toward statistical significance. Vitamin D deficiency is prevalent among patients with SLE in Jamaica. A relationship between low serum levels of vitamin D and SLE activity may occur.